Results 131 to 140 of about 1,114,410 (399)

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]

, 2002
Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R., Forster, Hubert, Hodges, Matthew, Hogan, Genevieve E., Papanek, Paula   +4 more
core   +2 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Infratemporal fossa approach: the modified zygomatico-transmandibular approach

Maxillofacial Plastic and Reconstructive Surgery, 2019
Background The infratemporal fossa (ITF) is an anatomical lateral skull base space composed by the zygoma, temporal, and the greater wing of the sphenoid bone. Due to its difficult approach, surgical intervention at the ITF has remained a heavy burden to
Soung Min Kim, Sun Ha Paek, Jong Ho Lee
doaj   +1 more source

Hypoxia signaling in human diseases and therapeutic targets

Experimental and Molecular Medicine, 2019
Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia signaling pathway have been performed. The role of HIF stabilization during hypoxia has been extended from the induction of a single gene erythropoietin to the ...
J. W. Lee, Junsuk Ko, C. Ju, H. Eltzschig   +3 more
semanticscholar   +1 more source

Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. [PDF]

, 2015
This study investigated the effects of continuous moderate-intensity exercise (MIE) and high-intensity interval exercise (HIIE) in combination with short exposure to hypoxia on appetite and plasma concentrations of acylated ghrelin, peptide YY (PYY), and
Alkahtani, Ariyasu, Banks, Bartlett, Bigaard, Borg, Bryna C. Chrismas, Burns, Canoy, Catenacci, Catherine J. Kerr, Charlot, Chelikani, Daniel P. Bailey, David J. Stensel, Debevec, Deighton, Deighton, Deighton, Dill, Evero, Faul, Flint, Gibala, Goodyear, Grafen, Hommel, Hosoda, Jessica A. Douglas, Kalson, Kayser, Kelly, Kessler, Kevin Deighton, King, Koliaki, Lee Taylor, Lindsey R. Smith, Loshbaugh, Martins, Mifflin, Morton, Murphy, Nakagawa, Ross, Saad, Schaller, Schubert, Sim, Snyder, Stubbs, Tsilchorozidou, Ueda, Ueda, Vandenbogaerde, Wasse, West, Westerterp-Plantenga, Williams, Wolff   +59 more
core   +3 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke

Chinese Medicine
Background Prognosis is critically important in stroke cases, with angiogenesis playing a key role in determining outcomes. This study aimed to investigate the potential protective effects of Atractylenolide I (Atr I), Atractylenolide III (Atr III), and ...
Haiyan Li, Wantong Yu, Yong Yang, Sijie Li, Jun Xu, Chen Gao, Wei Zhang, Wenjie Shi, Kunlin Jin, Xunming Ji, Changhong Ren   +10 more
doaj   +1 more source

Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis

Neoplasia: An International Journal for Oncology Research, 2022
Regions of low oxygen (hypoxia) are found in >50% of breast tumours, most frequently in the more aggressive triple negative breast cancer subtype (TNBC). Metastasis is the cause of 90% of breast cancer patient deaths. Regions of tumour hypoxia tend to be
Christopher Paul Carroll, Hannah Bolland, Eric Vancauwenberghe, Pamela Collier, Alison A. Ritchie, Philip A. Clarke, Anna M. Grabowska, Adrian L Harris, Alan McIntyre   +8 more
doaj  

Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress [PDF]

, 2019
Timely perception of adverse environmental changes is critical for survival. Dynamic changes in gases are important cues for plants to sense environmental perturbations, such as submergence. In Arabidopsis thaliana, changes in oxygen and nitric oxide (NO)
Bailey-Serres, Julia, Bassel, George W, Bosman, Femke, Gibbs, Daniel J, Hartman, Sjon, Hebelstrup, Kim H, Holdsworth, Michael J, Liu, Zeguang, Martopawiro, Shanice, Plant Ecophysiology, Reinen, Emilie, Sasidharan, Rashmi, Sub Plant Ecophysiology, Theodoulou, Frederica L, van Dongen, Nienke, van Veen, Hans, Vicente, Jorge, Visser, Eric J W, Voesenek, Laurentius A C J, Zhang, Hongtao   +19 more
core   +4 more sources