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Hypoxia. 5. Hypoxia and hematopoiesis

American Journal of Physiology-Cell Physiology, 2011
Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia ...
Donghoon, Yoon   +2 more
openaire   +2 more sources

Hypoxia city

Science, 2019
In a remote Andean mining town, scientists are studying how life at extremely low oxygen levels ravages the body.
openaire   +2 more sources

Hypoxia-inducible factors, hypoxia, and tumor angiogenesis

Current Opinion in Hematology, 2006
The transcription factor hypoxia-inducible factor is activated by low oxygen to promote the expression of target genes that allow cellular, tissue, and organismal adaptation to low oxygen. Hypoxia-inducible factor is activated not only by hypoxia but also as a consequence of genetic mutations in a variety of tumors.
Michaela, Gruber, M Celeste, Simon
openaire   +2 more sources

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