Results 211 to 220 of about 480,886 (266)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming. [PDF]

Front Immunol
Li S, Wei X, Han X, Wang J, Li N, Liu J, Zhang M.   +6 more
europepmc   +1 more source

Modified atmosphere under cold storage does not reduce phytosanitary irradiation efficacy for Drosophila suzukii (Diptera: Drosophilidae). [PDF]

J Econ Entomol
Gomes IV, Vera MT, Migliori A, Rempoulakis P, Stauffer C, Myers SW, Dias VS.   +6 more
europepmc   +1 more source

Hypoxia inducible factor-1α-driven signaling networks regulating adult neurogenesis via Notch, Wnt, and MAPK pathways. [PDF]

Mol Biol Rep
Cornelio-Martínez S, Lagunas-Rangel FA.
europepmc   +1 more source

HIF inhibition: Current strategies and clinical challenges. [PDF]

Redox Biol
Więch-Walów A, Bartoszewska S, Barton A, Czechowicz P, Dudzik J, Wielockx B, Collawn JF, Bartoszewski R.   +7 more
europepmc   +1 more source

TRIM25 enhances hypoxia signaling by catalyzing K11-linked polyubiquitination and stabilization of HIF-α. [PDF]

J Biol Chem
Li Z, Li J, Li Z, Wang R, Yuan L, Song Y, Wang Y, Yan R, Lai F, Wang J, Xiao W.   +10 more
europepmc   +1 more source

Hypoxia Impairs CD8⁺ T Cell Fitness and Is Associated with a Dysfunctional CD8⁺ T Cell State in Pancreatic Cancer. [PDF]

Cancers (Basel)
Mello AM, Pasca di Magliano M, Lee KE.
europepmc   +1 more source