Results 221 to 230 of about 939,686 (311)

Unraveling the complexity of cognitive impairment following high-altitude exposure: from preclinical animal models to human organoids. [PDF]

Front Neurosci
Gong H, Liu YX, Xiaoluo QL, Gong MF, Liu Z, Wu SR, Chen ZY, Liu TY, Zhao JH, Wang L, Fan XT, Xu HW.   +11 more
europepmc   +1 more source

The Burden of Brain Hypoxia and Optimal Mean Arterial Pressure in Patients With Hypoxic Ischemic Brain Injury After Cardiac Arrest*

, 2019
Mypinder S. Sekhon, Peter Gooderham, David K. Menon, Penelope M. A. Brasher, Denise Foster, Danilo Cardim, Marek Czosnyka, Peter Smielewski, Arun Kumar Gupta, Philip N. Ainslie, Donald Griesdale   +10 more
openalex   +2 more sources

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Harnessing NLRX1: a new frontier in mitigating inflammation in pulmonary hypertension. [PDF]

Respir Res
Xiao Y, Cai Z, Bai M, Wu X, Wang W, Liu R, Luo Y.   +6 more
europepmc   +1 more source

Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells

, 2011
Sandrine Chamboredon, Delphine Ciais, Agnès Desroches‐Castan, Pierre Savi, Françoise Bono, Jean‐Jacques Feige, Nadia Cherradi   +6 more
openalex   +2 more sources

Hypoxia Potentiates Nitric Oxide-mediated Apoptosis in Endothelial Cells via Peroxynitrite-induced Activation of Mitochondria-dependent and -independent Pathways [PDF]

, 2004
Geoffrey Walford, Rose‐Laure Moussignac, Anne Ward Scribner, Joseph Loscalzo, Jane A. Leopold   +4 more
openalex   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia. [PDF]

Cell Discov
Meng J, Zhang Y, Zhu M, Du Y, Yao Y, Liu S, He W, Zhu X.   +7 more
europepmc   +1 more source

In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo [PDF]

, 2005
Kang-Shen Yao, Jourik A. Gietema, S Shida, Muthu Selvakumaran, Xavier Fonrose, Naomi B. Haas, Joseph R. Testa, Peter J. O’Dwyer   +7 more
openalex   +1 more source