Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source
Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction. [PDF]
Gut MicrobesJacobs SO +8 more
europepmc +1 more source
Comparison of Adrenergic Activation by Anticholinesterases and by Hypoxia [PDF]
, 1962 V.M. Varagić, D.B. Beleslin
openalex +1 more source
Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair
Advanced Science, EarlyView.A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao +7 more
wiley +1 more source
Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function. [PDF]
Basic Clin Pharmacol ToxicolAlan-Albayrak E, Simonsen U.
europepmc +1 more source
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic Opportunities. [PDF]
Int J Mol SciVásquez Vélez IC +3 more
europepmc +1 more source
Hypoxia and the metabolic response to cold in new‐born rabbits
, 1964 Clark M. Blatteis
openalex +2 more sources
A METHOD FOR INDEPENDENT AND REVERSIBLE EXCLUSION OF CHANGES IN ACTIVITY OF THE CAROTID CHEMORECEPTORS AND BARORECEPTORS: STUDIES ON SYSTEMIC HYPOXIA [PDF]
, 1965 M. de Burgh Daly, Mary J. Scott
openalex +1 more source
Advanced Microfluidics for Single Cell‐Based Cancer Research
Advanced Science, EarlyView.Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro +10 more
wiley +1 more source