Results 261 to 270 of about 592,371 (315)

Astaxanthin effect on tissue transglutaminase expression in human neuronal differentiated stem cells exposed to hypoxia and hypoxia/reoxygenation. [PDF]

Sci Rep
Bonaventura G, Iemmolo R, Cognata V, Chiacchio MA, Sebastiano C, Pellitteri R, Campisi A.   +6 more
europepmc   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Hypoxia Independently Induces AID Expression in CH12 B Cells. [PDF]

Eur J Immunol
Heyer V, Haidar Ahmad S, Haddad M, Argentieri I, Gessier C, Reina-San-Martin B.   +5 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

CoCl₂-induced alterations in antioxidative and inflammatory marker expression in an siRNA-based in vitro model of aniridia-associated limbal epithelial dysfunction. [PDF]

BMC Ophthalmol
Hsu SL, Szentmáry N, Fries FN, Li Z, Chai N, Seitz B, Amini M, Suiwal S, Stachon T.   +8 more
europepmc   +1 more source

Effects and adaptation of high-altitude hypoxia on lipid metabolism: mechanisms and health implications. [PDF]

Front Physiol
Fan Y, Guo W, Yang L, Xu H.
europepmc   +1 more source

Hypoxia-selective targeting of eEF1A1: A promising therapeutic strategy for triple-negative breast cancer. [PDF]

Acta Pharm Sin B
Liang SH.
europepmc   +1 more source

Integrated Transcriptomic and Single-Cell Analyses Identify HILPDA as a Hypoxia-Mediated Regulator of Ferroptotic Signaling in Glioblastoma. [PDF]

Int J Mol Sci
Hacioglu N.
europepmc   +1 more source

Red Blood Cell Aggregation, Angiogenesis and Hypoxia Biomarkers in Pancreatic Cancer. [PDF]

J Clin Med
Wiewiora M, Andreade D, Heiliger C, Karcz K.   +3 more
europepmc   +1 more source