Results 301 to 310 of about 1,114,410 (399)

Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota. [PDF]

Sci Rep
Wen J, Wu Y, Zhang F, Wang Y, Yang A, Lu W, Zhao X, Tao H.   +7 more
europepmc   +1 more source

TERATOGENIC ACTION OF HYPOXIA ON THE CHICK EMBRYO : I. MALFORMATIONS OBSERVED IN SIX-DAY-OLD EMBRYOS

, 1964
Shutaro Yamamoto, Yuzo Noguchi
openalex   +2 more sources

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

<i>In vitro</i> study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions. [PDF]

Front Immunol
Ye Y, Wang Y, Xu Q, Liu J, Yang Z, Wuren T, Ge RL.   +6 more
europepmc   +1 more source

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

Advanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen, Gaoxiang Xu, Runpu Shen, Jianzhong Xu, Congcong Lu, Xin Li, Qi Feng, Qing Li   +7 more
wiley   +1 more source

Muscle deoxygenation responses are similar between repeated sprints in hypoxia performed with uni- versus bi-lateral knee extensions but reduced compared to cycling. [PDF]

Eur J Sport Sci
Mougin L, Millet GP, Vilmen C, Bendahan D, Rupp T.   +4 more
europepmc   +1 more source

TERATOGENIC ACTION OF HYPOXIA ON THE CHICK EMBRYO : II. MALFORMATIONS OBSERVED IN THE EIGHTEEN-DAY-OLD EMBRYO

, 1969
Yuzo Noguchi
openalex   +2 more sources

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathway. [PDF]

Sci Rep
Wen K, Zhang YT, Zhao QH, Li Q, Zhao JL, Ding Q, Xiao YF, Guan XH, Jiang MX, Qian YS, Tian XL, Wang LF, Deng KY, Xin HB.   +13 more
europepmc   +1 more source