Results 281 to 290 of about 1,127,805 (351)

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

Advanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng, Jiajing Xie, Luqi Wang, Hailong Xie, Tong Zhi, Yujia Guo, Bofeng Zhu, Dong Wang, Yu Chen   +8 more
wiley   +1 more source

Generation and Characterization of a Genetically Modified <i>Zea mays</i> Line with a Knockdown of Hypoxia-Dependent microRNA775A. [PDF]

Int J Mol Sci
Fedorin DN, Khomutova AE, Eprintsev AT, Igamberdiev AU.   +3 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants. [PDF]

Proc Natl Acad Sci U S A
Lavilla-Puerta M, He Y, Piccinini L, Paco LD, Papachristodoulou A, Licausi F, Giuntoli B.   +6 more
europepmc   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Effects of intermittent hypoxia and hypoxia-hyperoxia exposure on recovery from delayed onset muscle soreness in physically active men: protocol for a randomized controlled trial. [PDF]

Front Sports Act Living
Quiblier SPH, García-Pérez-de-Sevilla G, Santiago-Dorrego C, Iturriaga Ramírez T, Benítez-Valero R, Revuelta Parra C, Fernández Carrasco A, Domínguez-Balmaseda D.   +7 more
europepmc   +1 more source

Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models. [PDF]

Saudi Pharm J
Alotaibi AA, Habib SS, Gad H, Al Doheyan T, Aldosary M, Aljasham AT, Alotaibi AF, Alshawakir YA, Al-Masri AA.   +8 more
europepmc   +1 more source

The influence of hypoxia on tissue regeneration in oral and maxillofacial surgery - a systematic review. [PDF]

Clin Oral Investig
Gäde AHF, Schiegnitz E, Eckert AW, Sagheb K, Al-Nawas B, Kupka JR.   +5 more
europepmc   +1 more source

Identification of hypoxia-related gene signatures and molecular subtypes in chronic rhinosinusitis with nasal polyps. [PDF]

Braz J Otorhinolaryngol
Song L, Zhou S, Wang L, Lai J, Tan S, Yao C, Yu S.   +6 more
europepmc   +1 more source