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Machine learning and metabolic modeling-based identification of hypoxia-driven metabolic signatures in pediatric cancers. [PDF]
Front PharmacolSridhar S, Suraishkumar GK.
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Hypoxia Imaging As a Guide for Hypoxia-Modulated and Hypoxia-Activated Therapy
Antioxidants & Redox Signaling, 2022Significance: Oxygen imaging techniques, which can probe the spatiotemporal heterogeneity of tumor oxygenation, could be of significant clinical utility in radiation treatment planning and in evaluating the effectiveness of hypoxia-activated prodrugs.
Jeffrey R. Brender +4 more
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Hypoxia. 5. Hypoxia and hematopoiesis
American Journal of Physiology-Cell Physiology, 2011Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia ...
Donghoon, Yoon +2 more
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Journal of Applied Physiology, 2021
The word “hypoxia” has recently come to the attention of the general public on two occasions, the Nobel Prize in Medicine or Physiology in 2019 and the recent COVID-19 pandemic. In the academic environment, hypoxia is a current topic of research in biology, physiology, and medicine: in October 2020, there were more than 150,000 occurrences of “hypoxia”
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The word “hypoxia” has recently come to the attention of the general public on two occasions, the Nobel Prize in Medicine or Physiology in 2019 and the recent COVID-19 pandemic. In the academic environment, hypoxia is a current topic of research in biology, physiology, and medicine: in October 2020, there were more than 150,000 occurrences of “hypoxia”
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Placebo and nocebo effects are particularly relevant in hypoxia research. Studies performed at high-altitude environments have shown that placebos can partially mimic the effects of oxygen (O2) and compensate for some of the imbalances at the level of critical life functions, such as ventilation, circulation, and even performance.
Diletta, Barbiani +2 more
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Diletta, Barbiani +2 more
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Journal of Molecular and Cellular Cardiology, 1979
Abstract During hypoxia peak developed tension falls rapidly, resting tension inceeases slowly and recovery is incomplete if the hypoxia is sufficiently prolonged for resting tension to become greatly elevated. We propose that the initial fall of peak developed tension is due to a failure of excitation-contraction coupling at a time when high energy ...
W G, Nayler +2 more
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Abstract During hypoxia peak developed tension falls rapidly, resting tension inceeases slowly and recovery is incomplete if the hypoxia is sufficiently prolonged for resting tension to become greatly elevated. We propose that the initial fall of peak developed tension is due to a failure of excitation-contraction coupling at a time when high energy ...
W G, Nayler +2 more
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The British Journal of Radiology, 1970
The importance of hypoxia in radiobiology and radiotherapy continues to occupy much space in this journal (Littbrand and Revesz, 1969; Berry, Hall and Cavanagh, 1970). In spite of the excellent review by Boag (1969) we feel the pitfalls, namely: (a) variation in height of medium with its subsequent effect on oxygen diffusion and cell numbers; (b) the ...
J L, Moore, C W, Smith
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The importance of hypoxia in radiobiology and radiotherapy continues to occupy much space in this journal (Littbrand and Revesz, 1969; Berry, Hall and Cavanagh, 1970). In spite of the excellent review by Boag (1969) we feel the pitfalls, namely: (a) variation in height of medium with its subsequent effect on oxygen diffusion and cell numbers; (b) the ...
J L, Moore, C W, Smith
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Journal of Insect Physiology, 2001
Insects exhibit a remarkable array of adaptations that allow them to handle more or less severe hypoxia associated with numerous aquatic and terrestrial habitats. We consider these habitats and then discuss physiological, behavioral and morphological mechanisms that facilitate insect life under oxygen deprivation.
W W., Hoback, D W., Stanley
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Insects exhibit a remarkable array of adaptations that allow them to handle more or less severe hypoxia associated with numerous aquatic and terrestrial habitats. We consider these habitats and then discuss physiological, behavioral and morphological mechanisms that facilitate insect life under oxygen deprivation.
W W., Hoback, D W., Stanley
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