Results 1 to 10 of about 190,619 (239)
Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus. [PDF]
Extreme Physiology & Medicine, 2014 Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of this process remain controversial. Broadly, environmental hypoxia has been suggested to induce: (i) a loss of mitochondrial density; (ii) a substrate ...
Horscroft, James A, Murray, Andrew J
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Effects of Environmental and Pathological Hypoxia on Male Fertility [PDF]
Frontiers in Cell and Developmental Biology, 2021 Male infertility is a widespread health problem affecting approximately 6%–8% of the male population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are known, including environmental and pathological hypoxia. Studies looking at the effects of hypoxia on male infertility have linked both types of hypoxia to poor sperm quality ...
Zhibin Li +14 more
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The Influence of Environmental Hypoxia on Hemostasis—A Systematic Review [PDF]
Frontiers in Cardiovascular Medicine, 2022 Humans have been ascending to high altitudes for centuries, with a growing number of professional- and leisure-related sojourns occurring in this millennium. A multitude of scientific reports on hemostatic disorders at high altitude suggest that hypoxia is an independent risk factor.
Benedikt Treml +4 more
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Regulation of myogenesis by environmental hypoxia [PDF]
Journal of Cell Science, 2016 ABSTRACT In aerobic organisms, oxygen is a critical factor for tissue and organ morphogenesis from embryonic development throughout the adult life. It regulates various intracellular pathways involved in cellular metabolism, proliferation, cell survival and fate.
Magdalena Hidalgo +6 more
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Skin Hypoxia: A Promoting Environmental Factor in Melanomagenesis [PDF]
Cell Cycle, 2006 Melanomagenesis is a complex phenomenon in which environmental, genetic and host factors play a role. Sun burns in early childhood are a known risk factor in melanoma development. Alteration of prosurvival genes such as Ras and Akt and loss of function of the p16(INK4a)-CDK4/6-pRb and p14(ARF)-HDM2-p53 pathways are strongly associated with human ...
Marianne Broome Powell, Barbara Bedogni
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Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene [PDF]
Mutagenesis, 2014 Hypoxia promotes genetic instability and is therefore an important factor in carcinogenesis. We have previously shown that activation of the hypoxia responsive transcription factor HIFα can enhance the mutagenic phenotype induced by the environmental mutagen benzo[a]pyrene (BaP).
Marten A. Schults +5 more
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Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress [PDF]
, 2019 Timely perception of adverse environmental changes is critical for survival. Dynamic changes in gases are important cues for plants to sense environmental perturbations, such as submergence. In Arabidopsis thaliana, changes in oxygen and nitric oxide (NO)
Bailey-Serres, Julia +19 more
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The hypoxic transcription factor KlMga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis [PDF]
, 2019 Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes.
Bianchi, Michele M +7 more
core +1 more source
Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. [PDF]
, 2015 The effects of environmental hypoxia on cardiac and skeletal muscle metabolism are dependent on the duration and severity of hypoxic exposure, though factors which dictate the nature of the metabolic response to hypoxia are poorly understood.
core +2 more sources
Biogeochemical and environmental drivers of coastal hypoxia
Journal of Marine Systems, 2015 AbstractRecent reports have demonstrated that hypoxia is widespread in the coastal zone of the Baltic Sea. Here we evaluate the long-term trends of dissolved oxygen in bottom waters and of the drivers of coastal hypoxia. Eleven of the 33 sites evaluated had increasing trends of bottom water dissolved oxygen, but only the Stockholm Archipelago presents ...
Caballero-Alfonso, Angela M. +2 more
openaire +2 more sources