Results 91 to 100 of about 4,147,965 (342)

The hypoxia–reoxygenation stress in plants

Journal of Experimental Botany, 2020
Plants are very plastic in adapting growth and development to changing adverse environmental conditions. This feature will be essential for plants to survive climate changes characterized by extreme temperatures and rainfall.
J. León, M. Castillo, Beatriz Gayubas
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]

, 2002
Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R., Forster, Hubert, Hodges, Matthew, Hogan, Genevieve E., Papanek, Paula   +4 more
core   +2 more sources

Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

Open Biology
Orofacial clefts are the second-most prevalent congenital malformation. Risk factors are multifactorial and include genetic components, but also environmental factors.
Theresa Schmid, Gabriele Rodrian, Elke Bachmann, Alexander Kohler, Michael Wegner, Lina Gölz, Matthias Weider   +6 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice

Advanced Science, 2023
High altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and nutrition supply to the brain.
Shuoshuo Li, Wenyu Hu, Shenghui Gong, Ping Zhang, Jinbo Cheng, Shukun Wang, Yingyi Wang, Wenjun Shi, Qianqian Li, Fengchao Wang, Zengqiang Yuan   +10 more
doaj   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. [PDF]

PLoS ONE, 2015
Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not ...
Daniel Verduzco, Mark Lloyd, Liping Xu, Arig Ibrahim-Hashim, Yoganand Balagurunathan, Robert A Gatenby, Robert J Gillies   +6 more
doaj   +1 more source

Environmental filtering in marine fish communities is weakened during severe hypoxia season [PDF]

, 2021
Naoto Shinohara, Yuki Hongo, Momoko Ichinokawa, Shota Nishijima, Shuhei Sawayama, Hiroaki Kurogi, Yasuyuki Uto, Hisanori Mita, Mitsuhiro Ishii, Akane Kusano, Seiji Akimoto   +10 more
openalex   +1 more source

Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus

Extreme Physiology and Medicine, 2014
Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of this process remain controversial. Broadly, environmental hypoxia has been suggested to induce: (i) a loss of mitochondrial density; (ii) a substrate ...
J. Horscroft, A. Murray
semanticscholar   +1 more source