Results 121 to 130 of about 4,147,965 (342)

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Hypoxia and Sturgeons: report to the Chesapeake Bay Program Dissolved Oxygen Criteria Team [PDF]

, 2001
In this essay, three lines of evidence are developed that sturgeons in the Chesapeake Bay and elsewhere are unusually sensitive to hypoxic conditions: 1.
Niklitschek, Edwin J., Secor, David H.
core  

Environmental contaminants exposure and preterm birth: a systematic review [PDF]

, 2019
Preterm birth is an obstetric condition associated with a high risk of infant mortality and morbidities in both the neonatal period and later in life, which has also a significant public health impact because it carries an important societal economic ...
Benedetti Panici, Pierluigi, MASCIULLO, LUISA, Piacenti, Ilaria, Porpora, Maria Grazia, Rech, Francesco, Scaramuzzino, Sara   +5 more
core   +1 more source

Fluorescent Polymeric Nanofibers as Ratiometric Multiplexed Skin Sensors of pH and Oxygen

Advanced Healthcare Materials, EarlyView.
Fluorescent polymeric nanofibers and nanorods are produced as ratiometric sensors of two important physiological parameters: pH and oxygen. They operate by dual Forster resonance energy transfer from large number of energy donor dyes to limited number of two distinct energy acceptors, enabling simultaneous sensing of pH and oxygen.
Rémi Pelletier, Anila Hoskere Ashoka, Andrey S. Klymchenko   +2 more
wiley   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

3D Printing Strategies for Bioengineering Human Cornea

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in 3D bioprinting strategies for engineering human corneas. Key aspects include the replication of corneal transparency, curvature, and biomechanical properties, alongside innovations in recent advancements in 3D printing methods, which benefit in overcoming current challenges.
Yunong Yuan, Khoon S. Lim, Gerard Sutton, Gordon G. Wallace, Jingjing You   +4 more
wiley   +1 more source

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell [PDF]

, 2013
PubMed ID: 23592993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Castaneda-Garcia, A Di, A Kumar, AL Radtke, AM Cooper, BE Steinberg, BP Cormack, CE Barry 3rd, CM Sassetti, D Wagner, David G. Russell, DE Voth, DG Russell, DG Russell, H Barriere, H Ohno, HC Mwandumba, HD Park, J Rengarajan, JC Antoine, JL Flynn, K Pethe, K von Bargen, KH Rohde, LE Via, MI Voskuil, ND Sonawane, ND Sonawane, Neelima Sukumar, P Carroll, P Golby, PM Haggie, RB Abramovitch, RJ North, RM Yates, Robert B. Abramovitch, S Sturgill-Koszycki, S Sturgill-Koszycki, SB Walters, Shumin Tan, SM Payne, T Soldati, T Stauber, Tanya Parish, TB Reddy, UE Schaible, V Faundez, W Epstein, William R. Bishai   +48 more
core   +3 more sources

Similar fish species composition despite larger environmental heterogeneity during severe hypoxia in a coastal ecosystem

, 2022
Naoto Shinohara, Yuki Hongo, Momoko Ichinokawa, Shota Nishijima, Shuhei Sawayama, Hiroaki Kurogi, Yasuyuki Uto, Hisanori Mita, Mitsuhiro Ishii, Akane Kusano, Seiji Akimoto   +10 more
openalex   +1 more source

Growth Hormone‐Loaded 3D Printed Silk Fibroin‐Cellulose Dressings for Ischemic Wounds

Advanced Healthcare Materials, EarlyView.
3D‐printed wound dressings combining carboxymethyl cellulose, silk fibroin, and growth hormone accelerate healing in diabetic ulcers. These bioactive, customizable dressings enhance angiogenesis, cellular proliferation, and immune modulation. Proteomic analysis reveals activation of regenerative pathways and reduced fibrosis, highlighting their ...
Maria Pita‐Vilar, Diego Caicedo‐Valdés, Susana B. Bravo, Isabel Rodriguez‐Moldes, Salvador D. Aznar‐Cervantes, Angel Concheiro, Carmen Alvarez‐Lorenzo, Luis Diaz‐Gomez   +7 more
wiley   +1 more source

Effects of Hyperbaric Hypoxia on Some Enzyme Systems in the Mammalian Liver [PDF]

, 1978
The metabolic effects of hypobaric hypoxic stress on the mammalian liver were studied. The lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) activity of mouse liver homogenates were measured after exposure to an equivalent altitude of 36,000 ...
Baeyens, Dennis A., Meier, M. J.
core   +2 more sources