This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi +2 more
wiley +1 more source
Decades of Delay: EPA Leadership Still Lacking in Protecting America's Great River [PDF]
This report demonstrates the continuing failure of EPA's voluntary approach and the continuing and growing threats of unregulated nitrogen and phosphorus pollution.
Alicia Lloyd +13 more
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Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
Begley, J +11 more
core +2 more sources
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen +6 more
wiley +1 more source
Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance
The ubiquitin and hypoxia-inducible factor (HIF) pathways are cellular processes involved in the regulation of a variety of cellular functions. Enzymes called ubiquitin E3 ligases perform protein ubiquitylation.
Kateryna Kubaichuk, Thomas Kietzmann
doaj +1 more source
Phytoplankton Diversity as Ecological Indicator in Jimbaran Bay Waters [PDF]
A study was carried out to evaluate the ecological condition in Jimbaran Bay Waters by using Phytoplankton Diversity Index. The study was conducted at Balangan, Pemuda, Jimbaran, Kedonganan, Kelan and Segara Beach located in Jimbaran Bay. Shannon-Wiener
Perwira, I. Y. (Ima), Ulinuha, D. (Devi)
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Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López +5 more
wiley +1 more source
Establishing National Ocean Service Priorities for Estuarine, Coastal, and Ocean Modeling: Capabilities, Gaps, and Preliminary Prioritization Factors [PDF]
This report was developed to help establish National Ocean Service priorities and chart new directions for research and development of models for estuarine, coastal and ocean ecosystems based on user-driven requirements and supportive of sound coastal ...
Cloyd, Emily T. +3 more
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Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best +5 more
wiley +1 more source
Economic Impacts of Fall Commercial Nutrient Regulation [PDF]
Concern that nutrient (nitrogen (N) and phosphorus (P)) runoff are seriously contributing to hypoxia in the Gulf of Mexico has led some environmental groups to call for the banning of fall fertilizer applications; especially fall anhydrous ammonia ...
Otto, Daniel
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