Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy
Advanced Functional Materials, EarlyView.This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez +8 more
wiley +1 more source
The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice
Advanced Science, 2023 High altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and nutrition supply to the brain.
Shuoshuo Li +10 more
doaj +1 more source
Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks
Advanced Functional Materials, EarlyView.Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert +10 more
wiley +1 more source
Short-term acclimation in adults does not predict offspring acclimation potential to hypoxia
Scientific Reports, 2018 The prevalence of hypoxic areas in coastal waters is predicted to increase and lead to reduced biodiversity. While the adult stages of many estuarine invertebrates can cope with short periods of hypoxia, it remains unclear whether that ability is present
Manuela Truebano +6 more
doaj +1 more source
Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. [PDF]
PLoS ONE, 2015 Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not ...
Daniel Verduzco +6 more
doaj +1 more source
Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]
, 2007 Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E +2 more
core +2 more sources
Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes
Advanced Healthcare Materials, EarlyView.A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu +6 more
wiley +1 more source
Hypoxia-resistance heterogeneity in tumours: the impact of geometrical characterization of environmental niches and evolutionary trade-offs. A mathematical approach [PDF]
, 2023 Giulia Chiari +2 more
openalex +1 more source
Laser‐Assisted Processing and Modification of Bioactive Glasses: A Review
Advanced Healthcare Materials, EarlyView.Laser technologies provide powerful tools to process and transform bioactive glasses for advanced biomedical applications. This review discusses laser‐matter interaction mechanisms, laser surface engineering, and laser‐assisted fabrication of scaffolds and nanofibers.
Antonio Riveiro +8 more
wiley +1 more source
Tendinosis develops from age- and oxygen tension-dependent modulation of Rac1 activity. [PDF]
, 2019 Age-related tendon degeneration (tendinosis) is characterized by a phenotypic change in which tenocytes display characteristics of fibrochondrocytes and mineralized fibrochondrocytes.
Edwards, Richard W. +7 more
core +2 more sources