Results 181 to 190 of about 4,650,121 (384)

Combined effects of normobaric hypoxia and cold on respiratory system responses to high‐intensity exercise

Experimental Physiology
Cold temperatures (
Alexa Callovini, Alessandro Fornasiero, Aldo Savoldelli, Gianluigi Dorelli, Marco Decet, Lorenzo Bortolan, Barbara Pellegrini, Federico Schena   +7 more
doaj   +1 more source

A Physically Driven Interpretable Machine Learning Framework for Early Forecasting of Summer Hypoxia in the Semi-Enclosed Bohai Sea Using Remote Sensing Data

Remote Sensing
Hypoxia has become increasingly frequent in the semi-enclosed Bohai Sea since the early 2000s, posing significant risks to marine ecosystems. To address the limitations of existing dissolved oxygen models—particularly their poor predictive ability and ...
Yong Jin, Jie Guo, Shanwei Liu, Tao Li, Hansen Yue, Diansheng Ji, Chawei Hou, Haitian Tang   +7 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Root O₂ consumption, CO₂ production and tissue concentration profiles in chickpea, as influenced by environmental hypoxia [PDF]

, 2019
Timothy D. Colmer, Anders Winkel, Lukasz Kotula, W. Armstrong, Niels Peter Revsbech, Ole Pedersen   +5 more
openalex   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

The physiology and biomechanics of avian flight at high altitude [PDF]

, 2006
Many birds fly at high altitude, either during long-distance flights or by virtue of residence in high-elevation habitats. Among the many environmental features that vary systematically with altitude, five have significant consequences for avian flight ...
Altshuler, Douglas L., Dudley, Robert
core  

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Peer Review #2 of "Effects of environmental hypoxia and hypercarbia on ventilation and gas exchange in Testudines (v0.1)"

, 2018
T Wang
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source