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Identifying Genetic Susceptibility in Neonates With Hypoxic-Ischemic Encephalopathy: A Retrospective Case Series

Journal of Child Neurology, 2023
Neonatal hypoxic-ischemic encephalopathy is a clinical phenomenon that often results from perinatal asphyxia. To mitigate secondary neurologic injury, prompt initial assessment and diagnosis is needed to identify patients eligible for therapeutic ...
K. Woodward   +4 more
semanticscholar   +1 more source

Brain injury patterns in hypoxic ischemic encephalopathy of term neonates

Journal of Neuroimaging, 2022
Topographic patterns of brain injury in neonates can help with differentiation and prognostic categorization of hypoxic ischemic encephalopathy (HIE). In this study, we quantitatively and objectively characterized the location of hypoxic ischemic lesions
Pratheek S Bobba   +5 more
semanticscholar   +1 more source

The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.

Clinics of Perinatology, 2021
Neonatal encephalopathy due to perinatal hypoxia-ischemia (hypoxic-ischemic encephalopathy [HIE]) occurs at a rate of 1 to 3 per 1000 live births. Therapeutic hypothermia is the standard of care and the only currently available therapy to reduce the risk
S. Bonifacio, Shandee Hutson
semanticscholar   +1 more source

Hypoxic Ischemic Encephalopathy (Asphyxia)

Pediatric Clinics of North America, 1986
This article concerns itself with the effects of HIE on the brain of the full-term infant. Several treatment options are available, with phenobarbital being the drug of choice, but the course remains observation and careful monitoring of the at-risk infant.
openaire   +2 more sources

Neonatal encephalopathy: Etiologies other than hypoxic-ischemic encephalopathy.

Seminars in Fetal & Neonatal Medicine, 2021
Neonatal encephalopathy (NE) describes the clinical syndrome of a newborn with abnormal brain function that may result from a variety of etiologies. HIE should be distinguished from neonatal encephalopathy due to other causes using data gathered from the
A. G. Sandoval Karamian   +7 more
semanticscholar   +1 more source

Neonatal encephalopathy and hypoxic–ischemic encephalopathy

2019
Acute hypoxic-ischemic encephalopathy around the time of birth remains a major cause of death and life-long disability. The key insight that led to the modern revival of studies of neuroprotection was that, after profound asphyxia, many brain cells show initial recovery from the insult during a short "latent" phase, typically lasting approximately 6h ...
Gunn, A, Thoresen, Marianne
openaire   +3 more sources

Diagnostic Role of Systemic Inflammatory Indices in Infants with Moderate-to-Severe Hypoxic Ischemic Encephalopathy

American Journal of Perinatology, 2021
Background  When the newborn brain is exposed to hypoxia, as in hypoxic ischemic encephalopathy (HIE), it causes an inflammatory response. A wide variety of inflammatory markers are therefore used in the diagnosis of HIE. Objective  We aimed to determine
Burak Ceran   +4 more
semanticscholar   +1 more source

Hypoxic-Ischemic Encephalopathy

2021
Hypoxic-ischemic encephalopathy (HIE) or perinatal asphyxia occurs in one to three per thousand live births at term. The results of HIE are devastating and permanent, making it a great burden for the patient, family, and society. The neuropathological characteristics of perinatal asphyxia can vary considerably with the child’s gestational age, the ...
openaire   +1 more source

Hypothermia for Hypoxic-Ischemic Encephalopathy

Clinics in Perinatology, 2008
We are entering an era in which hypothermia will be used in combination with other novel neuroprotective interventions. The targeting of multiple sites in the cascade leading to brain injury may prove to be a more effective treatment strategy after hypoxic-ischemic encephalopathy in newborn infants than hypothermia alone.
Rakesh, Sahni, Ulana M, Sanocka
openaire   +2 more sources

Management of Hypoxic-ischemic Encephalopathy

The Indian Journal of Pediatrics, 2014
Hypoxic-ischemic encephalopathy (HIE), also termed as ‘perinatal asphyxia’ is a medical condition characterized by clinical and laboratory evidence of acute or sub-acute brain injury related to perinatal hypoxic-ischemic event in the neonate. HIE is a major cause of perinatal mortality and cerebral palsy worldwide and affects 2 in 1000 neonates [1].
Siba Prosad, Paul   +2 more
openaire   +2 more sources

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