Results 51 to 60 of about 17,799,762 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Embedded discontinuities for 3D mode-I and mode-II failure modelling

Computer Assisted Methods in Engineering and Science, 2023
The incorporation of displacement discontinuities in finite elements is examined. The incorporation of displacement discontinuities allows the use of discrete constitutive models in a continuum framework in order to avoid the mesh sensitivity of ...
Garth N. Wells, Lambertus J. Sluys
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Experimental identification of I-mode characteristics at the edge of FIRE mode in KSTAR

Nuclear Fusion
The edge region of the recently discovered fast ion-regulated enhancement mode (FIRE mode) (Han and Park et al 2022 Nature 609 269–275), which primarily operates in the unfavorable ion $\nabla B$ drift configuration, is investigated in detail for the ...
Chweeho Heo, SangJin Park, GyungJin Choi, Jaewook Kim, Eun-jin Kim, YoungMu Jeon, Minjun J. Choi, Hyunsun Han, Choongki Sung, TaikSoo Hahm, Yong-Su Na   +10 more
doaj   +1 more source

Mode I and Mode II Fracture Toughness of Fe-based Amorphous Materials: Theoretical and Empirical Investigations [PDF]

Journal of Applied and Computational Mechanics
This study investigates a diagonally loaded square plate specimen's fracture toughness. The specimen has central pre-crakes under loading modes I and II. Iron-based amorphous material with high strain-hardness (200 to 500 MPa) and malleability (10% to 50%
Hamid Al-Abboodi, Mortadha Razzaq
doaj   +1 more source

An extended mode-matching model for improved relative permittivity measurements using a split-cylinder resonator [PDF]

Advances in Radio Science, 2014
In this paper we present an extended mode-matching model for a split-cylinder resonator involving TE and TM resonant modes. The new model enhances the known TE0np mode-matching model by improving mode identification and distortion analysis and providing ...
S. Zinal, U. Arz
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dynamic properties of mode I and mode II fractures of shale under impact loading

Journal of Rock Mechanics and Geotechnical Engineering
Controllable shock wave fracturing is an innovative engineering technique used for shale reservoir fracturing and reformation. Understanding the anisotropic fracture mechanism of shale under impact loading is vital for optimizing shock wave fracturing ...
Zelin Yan, Linjuan Wang, Jidong Jin, Jianxiang Wang   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Numerical study of upper hybrid to Z-mode leakage during electromagnetic pumping of groups of striations in the ionosphere [PDF]

Annales Geophysicae, 2015
We investigate numerically the interaction between ionospheric magnetic field-aligned density striations and a left-hand circularly polarized (L)-mode wave.
B. Eliasson, T. B. Leyser
doaj   +1 more source