Results 61 to 70 of about 17,799,762 (307)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2023 Mode-I fracture toughness test provides valuable information in the thickness direction of fiber reinforced polymer matrix composites. However, damage propagation under mode-I loading is dependent on the configuration of reinforcing material of the ...
Yıldız, Mehmet +14 more
core +1 more source
High confinement regimes on SPARC: operational conditions for access and avoidance
Nuclear FusionThis work examines H-mode and I-mode access on the SPARC tokamak, combining new simulations of core L-mode power balance with the best empirical scalings available for L–H and L–I thresholds.
J.W. Hughes +8 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
External cavity mode structure of a two-mode VCSEL subject to optical feedback
, 2007 We consider a multi-transverse-mode vertical-cavity surface-emitting laser (VCSEL) subject to optical feedback. The system is modeled by a partial differential equation for the spatial carrier population, which is coupled to delay differential equations ...
Green, K +5 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Mode I and Mode II Crack Tip Asymptotic Fields with Strain Gradient Effects
, 2001 The strain gradient effect becomes significant when the size of fracture process zone around a crack tip is comparable to the intrinsic material length l, typically of the order of microns.
Chen, SH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100080, Peoples R China. +2 more
core
Identification of mode couplings in nonlinear vibrations of the steelpan [PDF]
, 2014 The authors are grateful to Bertrand David (Telecom-ParisTech) for computing the code allowing the STFT filtering procedure used in Section 5.1. The filter has been designed in the framework of the PAFI project (Plateforme d’Aide la facture Instrumentale,
TOUZÉ, Cyril +2 more
core +1 more source