Results 11 to 20 of about 3,004 (138)

The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir [PDF]

Archives of Virology
AbstractGenetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic preparedness, but the susceptibility of zoonotic IAVs to the cap-dependent endonuclease inhibitor baloxavir acid (BXA) has not been thoroughly researched. Although an amino acid substitution
Takao Shishido, Hiroshi Kida, Keiichi Taniguchi   +2 more
exaly   +4 more sources

Treatment-Emergent Influenza Virus Polymerase Acidic Substitutions Independent of Those at I38 Associated With Reduced Baloxavir Susceptibility and Virus Rebound in Trials of Baloxavir Marboxil [PDF]

Journal of Infectious Diseases, 2020
AbstractInfluenza viruses harboring treatment-emergent I38F/M/N/T substitutions in the polymerase acidic (PA) endonuclease exhibited reduced susceptibility to baloxavir and were associated with virus rebound and variable clinical response in clinical trials.
William L, Ince, Fraser B, Smith, Julian J, O'Rear, Michael, Thomson   +3 more
exaly   +3 more sources

A Sequence-Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Martín-Toribio A, Inchausti-Moya I, Toquero-Asensio M, García-Díaz S, Sanchez-Martinez J, Rodriguez-Crespo C, Galindo-Carretero S, Iglesia-Aparicio R, Lopez-Gonzalo C, Antón-Contreras A, Rojo-Rello S, Dominguez-Gil M, Hernández M, Eiros JM, Nistal-Villan E, Sanz-Muñoz I.   +15 more
europepmc   +2 more sources

I38 Rheumatology in Interesting Times [PDF]

Rheumatology, 2016
Dacre Jane
exaly   +2 more sources

I38. BIOLOGICS AND SAFETY ISSUES GUIDELINE [PDF]

Rheumatology, 2017
exaly   +2 more sources

I38. Innate Lymphoid Cells and Stroma in Inflammation and Tissue Pathology [PDF]

Rheumatology, 2015
exaly   +2 more sources

An Analysis of the Public Distribution System in Rural Haryana, India

Studia Ekonomiczne i Regionalne, 2023
The present paper aims to analyze the functioning and coverage of the public distribution system in rural Haryana, India.
Devi Seema, Siwach Manoj
doaj   +1 more source

Examining the impact of rural finance development on farmers’ incomes in business context. Evidence from “The Belt and Road” from key provinces

Financial Internet Quarterly, 2023
The gradual increase in the world population has a significant impact on businesses, productivity, and financial development in the context of rural life.
Qiu-Bin Lin, Döngül Esra Sipahi, Ul-Durar Shajara   +2 more
doaj   +1 more source

Igualdad de género y autonomía de las mujeres en el pensamiento de la CEPAL

El Trimestre Económico, 2022
Este artículo recorre los principales conceptos e hitos sobre igualdad de género y autonomía de las mujeres en la producción de la Comisión Económica para América Latina y el Caribe (CEPAL) y su vinculación con los debates y los acuerdos alcanzados en la
Ana Güezmes, Lucía Scuro, Nicole Bidegain   +2 more
doaj   +1 more source

European COVID -19 Pandemic Data and Social Inclusion Policy in the European Union: Drivers-Driven Trend Analysis

Economics and Culture, 2021
Research purpose. The study is focused on the Covid-19 pandemic crisis in the European Union. This study investigates the current driving trends and trade-offs of the Covid-19 pandemic phenomenon and social inclusion trends in the European countries.
Kaivo-oja Jari, Aho Samuli, Lauraéus Theresa   +2 more
doaj   +1 more source