Results 141 to 150 of about 74,470 (292)
The FEBS Journal, EarlyView.Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht +6 more
wiley +1 more source
IBA-Machbarkeitsstudie Deichpark Elbinsel [PDF]
, 2011 IBA-MACHBARKEITSSTUDIE DEICHPARK ELBINSEL IBA-Machbarkeitsstudie Deichpark Elbinsel / Metzger, Sabine [Hrsg.] (Rights reserved) (-
Metzger, Sabine [Hrsg.]
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S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea
The FEBS Journal, EarlyView.S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels +7 more
wiley +1 more source
Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa
The FEBS Journal, EarlyView.Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley +1 more source
Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community
Haemophilia, EarlyView.ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein +6 more
wiley +1 more source
, 2013 BAUSTELLE IBA HAMBURG Baunetzwoche (Rights reserved) (-) Ausgabe 312.2013 Baustelle IBA Hamburg (Rights reserved) (-
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Plant Biotechnology Journal, EarlyView.Proposed model of TAC1‐mediated leaf angle regulation in tobacco. ABSTRACT Plant architecture is key to crop yield, with leaf angle being critical for high‐density cultivation. Although TAC1 represents a promising regulator of leaf angle for breeding, its molecular mechanism remains poorly understood, particularly at single‐nucleus resolution. Here, we
Lin Wang +11 more
wiley +1 more source