Results 51 to 60 of about 90,457 (287)

IBA Alumni e-Magazine [Jul-Sep 2014]

open access: yes, 2022
This newsletter covers new heights and achieved milestones attained by IBA Alumni during July-September 2014https://ir.iba.edu.pk/iba-alumni-magazine/1004/thumbnail ...
Alumni & Resource Mobilization Department, IBA
core  

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

open access: yesAdvanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang   +12 more
wiley   +1 more source

Momentum and disposition effect in the US stock market

open access: yesCogent Economics & Finance, 2021
This paper examines whether momentum drives the disposition effect and vice versa in the US stock market. The results from the analysis of the Fama-Macbethregressions show that the disposition effect drives momentum but not the other way around ...
Ranjeeta Sadhwani, M. U. R. Bhayo
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

open access: yesAdvanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong   +8 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

open access: yesAdvanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin   +3 more
wiley   +1 more source

Clonal Propagation of Flacourtia indica for Ensuring Quality Planting Materials and Sustainable Supply of Edible Fruits

open access: yesInternational Journal of Agriculture System, 2017
The present study was carried out at the Agriculture research field, Patuakhali Science And Technology University(PSTU), Patuakhali, from March, 2015 to April, 2016 to explore the domestication potential and to evaluate the rooting performance of ...
Md. Alamgir Kabir   +6 more
doaj   +1 more source

Effect of IBA on Growth of Doritaenopsis Plantlets In Vitro

open access: yes, 2014
本試驗利用朵麓蝶蘭Dtps. Minho Rose × Dtps. Tinny Roseheart 分生瓶苗為試驗材料,探討培表基內IBA濃度對瓶苗生長的影響。培養基添加5mg/IBA處理者瓶苗之乙烯產量最高,瓶苗根數及根直徑增加,且根長變短,培殖體全可溶性糖、澱粉含量及培殖體的乾、鮮重提高。培養基添加15及2Omg/IBA後,瓶苗葉長、寬、根數、葉片與根部乾、鮮重均降低。試驗結果顯示培養基內添加適量IBA濃度,可促進朵麗蝶蘭瓶苗的生長。Effects of IBA concentration in ...
林瑞松   +3 more
core  

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

open access: yesAdvanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong   +17 more
wiley   +1 more source

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