Results 121 to 130 of about 145,684 (315)

Smoking in inflammatory bowel diseases: Good, bad or ugly?

, 2007
Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn’s disease (CD).
Peter Laszlo Lakatos, Lakatos, Péter László, Tamas Szamosi, Szamosi, Tamás, Laszlo Lakatos, Lakatos, László   +5 more
core   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

The biological therapy of IBD with special regards to its problems

, 2015
Biological therapy is a relatively new form of treatments. Many different therapeutic approaches can be cathegorized as biologics and many new agents may be classified unto them.
Olajos, Dániel Péter
core  

A Practical Gut‐On‐Chip Workflow for Imaging‐Based Assessment of Epithelial Barrier Dynamics During E. coli Co‐Culture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The intestinal epithelium and its resident microbiota form a dynamic interface that is central to gut homeostasis, but this interface is difficult to model with conventional tools. Static Transwell cultures lack physiological fluid shear, whereas animal models are costly and poorly suited to quantitative, high‐content imaging.
Shih‐Wei Chiang, Chuan‐Yi Yang, Guan‐Yu Chen   +2 more
wiley   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Antimicrobial studies of Ficus benghalensis and Ficus racemosa on pathogenic viral diseases [PDF]

Advanced Herbal Medicine, 2017
Background and aims: Medicinal plant products are considered to be an effective candidate against the number of viral diseases as generally observed or reported in developing countries. As per the literature, secondary metabolites (i.e.
Amit Gupta, Sushama Chaphalkar
doaj  

ECCO IBD Curriculum [PDF]

Journal of Crohn's and Colitis, 2017
Lindsay J. O., Irving P. M., Mantzaris G. J., Panes J., Lopez-Sanroman A., Katsanos K., Juillerat P., Maconi G., Lakatos P., Annese V., Armuzzi A., Bager P., Bettenworth D., Chauhan U. K., Ding N. S., Feakins R. M., Fiorino G., Gisbert J., Kierkus J., Levine A., Peyrin-Biroulet L., Rieder F., Russell R., Siegmund B., Spinelli A., Sturm A., Turner D., Van Rheenen P., Vavricka S., Zagorowicz E., Hogenauer C., Bossuyt P., Bogut A., Knudsen T., af Bjorkesten C. -G., Molander P., Bourreille A., Koutroubakis J., Ellul P., Vieira A. I., Diculescu M. M., Drobne D., Strid H., Celik A. F., Hawthorne B.   +44 more
openaire   +4 more sources

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

A machine learning framework reveals key drivers of cytokine responses in a healthy human cohort

npj Systems Biology and Applications
Population based studies are essential to evaluate the impact of the genetic and environmental determinants that influence the regulation of the human immune response.
Claire Liefferinckx, Jérémie Bottieau, Eric Quertinmont, Vjola Tafciu, Charlotte Minsart, Denis Franchimont   +5 more
doaj   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source