Results 81 to 90 of about 232,968 (298)

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis [PDF]

, 2014
Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent.
Abraham, Amre, Andrew R. Hart, Anja Olsen, Anne Tjonneland, Antoine Racine, Antonia Trichopoulou, Bas Oldenburg, Bennett, Bernstein, Bianchi Porro, Bingham, Bohlscheid-Thomas, Calkins, Chan, Darmon, De Filippo, Domenico Palli, Essebag, Fiona van Schaik, Francesca L. Crowe, Franck Carbonnel, Gaboriau-Routhiau, Geerling, Giovanna Masala, Göran Hallmans, H. Bas Bueno-de-Mesquita, Hart, Heresbach, Hou, Iwaya, Jantchou, Jarnerot, Jostins, Kaaks, Kasper, Katsouyanni, Kay-Tee Khaw, Kim Overvad, Kurakevich, Kurata, Maconi, Manuela M. Bergmann, Margetts, Marie-Christine Boutron-Ruault, Martinez-Medina, Maslowski, Mendall, Moreno-Navarrete, Ocke, Olof Grip, Orholm, Peeters, Persson, Pisani, Pontus Karling, Poullis, Prynne, Quezada, Reif, Riboli, Riboli, Robert Luben, Rosario Tumino, Rudolf Kaaks, Sakamoto, Sartor, Satsangi, Shivananda, Silkoff, Simon S. M. Chan, Slimani, Sonnenberg, Spooren, Stefan Lindgren, Thia, Thornton, Timothy Key, Tjonneland, Tragnone, Turnbaugh, van Liere, Wen, Zhang   +83 more
core   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

The Risk of Cerebrovascular Accidents in Inflammatory Bowel Disease in the United States: A Population-Based National Study

Clinical and Experimental Gastroenterology, 2020
Sara Ghoneim,1 Aun Shah,1 Aneesh Dhorepatil,1 Muhammad Umer Butt,2 Nisheet Waghray3 1Department of Internal Medicine, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA; 2Division of Cardiology, Case Western Reserve ...
Ghoneim S, Shah A, Dhorepatil A, Butt MU, Waghray N   +4 more
doaj  

Inflammatory Bowel Disease Etiology: Current Knowledge

Pteridines, 2018
Non-specific inflammatory bowel diseases (IBD) include Crohn’s disease (CD) and ulcerative colitis (UC). Both diseases are characterized by chronic inflammation of unclear etiology.
Kikut Justyna, Konecka Nina, Ziętek Maciej, Szczuko Małgorzata   +3 more
doaj   +1 more source

Clinical management of severe active ulcerative colitis in the TNF-a inhibitors era

Italian Journal of Medicine, 2013
Ulcerative colitis (UC) is a chronic inflammation of the coli mucosa clinically characterized by bloody diarrhea, abdominal pain and other systemic symptoms.
Andrea Calafiore, Fernando Rizzello, Chiara Praticò, Paolo Gionchetti, Carlo Calabrese, Giuseppina Liguori, Massimo Campieri   +6 more
doaj   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Gastrointestinal ultrasound in inflammatory bowel disease care: Patient perceptions and impact on disease‐related knowledge

JGH Open, 2020
Background and Aim Objective monitoring of disease activity is integral to therapeutic decision‐making in inflammatory bowel disease (IBD). Data are sparse on patients' perspectives of tools used to monitor disease activity in IBD.
Arvind Rajagopalan, Dharshan Sathananthan, Yoon‐Kyo An, Lucinda Van De Ven, Serena Martin, James Fon, Samuel P Costello, Jakob Begun, Robert V Bryant   +8 more
doaj   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source