Results 61 to 70 of about 232,968 (298)

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Efficacy and Safety of Switching From Intravenous to Subcutaneous Vedolizumab in Japanese Patients With Ulcerative Colitis: A Study Focusing on Injection‐Site Reactions

JGH Open
Background/Aims The subcutaneous (SC) formulation of vedolizumab is available as an alternative to the intravenous (IV) formulation in patients with ulcerative colitis (UC).
Makoto Furuya, Kiichiro Yoza, Takeshi Yonezawa, Ken Takeuchi   +3 more
doaj   +1 more source

The influence of physiotherapy on the treatment of inflammatory bowel diseases – a short overview

Journal of Education, Health and Sport, 2018
Background of Inflammatory diseases of the intestines affect more and more people, this is caused not only by genetic determinants but also by environmental conditions and lifestyle.
Bartłomiej Wrzesiński, Edyta Piechocka, Paweł Wojtczak, Anna Ziółkowska, Angelika Szustka, Kamila Balcerska, Marta Bielejewska, Patrycja Łopatka   +7 more
doaj   +1 more source

The geography of recent genetic ancestry across Europe [PDF]

, 2013
The recent genealogical history of human populations is a complex mosaic formed by individual migration, large-scale population movements, and other demographic events.
A Albrechtsen, A Auton, A Gillett, A Gusev, A Keller, A Zeileis, AE Hoerl, AL Price, AL Price, AM Stuart, B Winney, BL Browning, BM Henn, BM Henn, C Tyler-Smith, CD Huff, Chris Tyler-Smith, CL Epstein, CT O'Dushlaine, DJ Lawson, DLT Rohde, E Jakkula, F Rousset, G McVean, Graham Coop, H Li, J Chang, J Novembre, J Novembre, J Novembre, JA Tennessen, JE Pool, JE Powell, JFC Kingman, JK Gusev, Lowe, JN Fenner, K Harris, KA Frazer, KP Donnelly, M Slatkin, MD Brown, MR Nelson, MR Nelson, N Patterson, N Patterson, N Takahata, NH Chapman, O Lao, P Menozzi, P Moorjani, P Skoglund, P Soares, Peter Ralph, PF Palamara, R Hudson, RA Fisher, RL Cann, S Carmi, S Giglio, S Gravel, S Purcell, Y Petrov   +61 more
core   +4 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut–Kidney Axis

Life
Inflammatory bowel disease (IBD) can extend beyond the gastrointestinal tract, affecting extraintestinal organs and significantly increasing morbidity and mortality.
Roberto de Sire, Alessia La Mantia, Livio Bonacci, Anna Testa, Alessia Dalila Guarino, Antonio Rispo, Olga Maria Nardone, Fabiana Castiglione   +7 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay

, 2017
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta ...
An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Caicedo, D. A. Martinez, Cao, D., Cao, G. F., Cao, J., Chan, Y. L., Chang, J. F., Chang, Y., Chen, H. S., Chen, Q. Y., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Chukanov, A., Cummings, J. P., Ding, Y. Y., Diwan, M. V., Dolgareva, M., Dove, J., Dwyer, D. A., Edwards, W. R., Gill, R., Gonchar, M., Gong, G. H., Gong, H., Grassi, M., Gu, W. Q., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, E. C., Huang, H. X., Huang, X. T., Huang, Y. B., Huber, P., Huo, W., Hussain, G., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Jiao, J. B., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Khan, A., Kohn, S., Kramer, M., Kwan, K. K., Kwok, M. W., Langford, T. J., Lau, K., Lebanowski, L., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, C., Li, D. J., Li, F., Li, G. S., Li, Q. J., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Lin, S. K., Lin, Y. -C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Loh, C. W., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., McDonald, K. T., McKeown, R. D., Mitchell, I., Nakajima, Y., Napolitano, J., Naumov, D., Naumova, E., Ngai, H. Y., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Pec, V., Peng, J. C., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Qiu, R. M., Raper, N., Ren, J., Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Stoler, P., Sun, J. L., Tang, W., Taychenachev, D., Treskov, K., Tsang, K. V., Tull, C. E., Viaux, N., Viren, B., Vorobel, V., Wang, C. H., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z., Wang, Z. M., Wei, H. Y., Wen, L. J., Whisnant, K., White, C. G., Whitehead, L., Wise, T., Wong, H. L. H., Wong, S. C. F., Worcester, E., Wu, C. -H., Wu, Q., Wu, W. J., Xia, D. M., Xia, J. K., Xing, Z. Z., Xu, J. L., Xu, Y., Xue, T., Yang, C. G., Yang, H., Yang, L., Yang, M. S., Yang, M. T., Yang, Y. Z., Ye, M., Ye, Z., Yeh, M., Young, B. L., Yu, Z. Y., Zeng, S., Zhan, L., Zhang, C., Zhang, C. C., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, R., Zhang, X. T., Zhang, Y. M., Zhang, Y. M., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., Zhuang, H. L., Zou, J. H.   +204 more
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source