Results 61 to 70 of about 160,408 (307)

Current trends and future perspectives of natural polymer loaded nanoparticle based drug delivery system for the management of inflammatory bowel disease

Journal of Applied Pharmaceutical Research, 2023
Targeting the drug delivery system is very tough nowadays due to premature drug release at the upper GIT tract and altered pH conditions. Colon-specific drug delivery systems can overcome that problem using different polymer combinations.
Ankita Basak, Soumyadip Ghosh, Debgopal Ganguly, Soukat Garain, Riya Ghosh, Ananta Choudhury, Himangshu Deka, Jahnabi Sarmah   +7 more
doaj   +1 more source

The development and initial findings of a study of a prospective adult research cohort with inflammatory bowel disease (SPARC IBD)

, 2021
Background: Clinical and molecular subcategories of inflammatory bowel disease (IBD) are needed to discover mechanisms of disease and predictors of response and disease relapse. We aimed to develop a study of a prospective adult research cohort with IBD (
O’Charoen, Sirimon, Yarur, Andres, Sara Sweeney, Dalal, Sushila, Matthew Bohm, Caldera, Freddy, Tara Fehlmann, Wells, Katerina, Joel Pekow, Snapper, Scott, Monika Fischer, Dobes, Angela, Themistocles Dassopoulos, Perera, Lilani, Duerr, Richard, Cecile Norris, Pekow, Joel, Angela Dobes, Elizabeth A Scoville, Shrinivas Bishu, David Hudesman, O\u27Charoen, Sirimon, Scott Snapper, Scoville, Elizabeth A., Lewis, James D, Bohm, Matthew, Sirimon O’Charoen, Richard Duerr, Laura E Raffals, Katerina Wells, Sumona Saha, Uni Wong, Lilani Perera, Bishu, Shrinivas, Alandra Weaver, Fischer, Monika, Parakkal, Deepak, Wong, Uni, Sweeney, Sara, Freddy Caldera, James D Lewis, Meenakshi Bewtra, Raymond Cross, Raffals, Laura E, Norris, Cecile, Cross, Raymond, Heller, Caren, Lewis, James D., Hudesman, David, Kaur, Manreet, Andres Yarur, Weaver, Alandra, Caren Heller, Korzenik, Joshua, Raffals, Laura E., Scoville, Elizabeth A, Sushila Dalal, Joshua Korzenik, Deepak Parakkal, Manreet Kaur, Matthew Ciorba, Saha, Sumona, Fehlmann, Tara, Dassopoulos, Themistocles, Bewtra, Meenakshi, Ciorba, Matthew   +65 more
core   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study [PDF]

, 2019
BACKGROUND/AIMS Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS)
Rogler, Gerhard, Nicolas Fournier, Vavricka, Stephan R., Rogler, G., Butter, M., Navarini, A.A., Luc Biedermann, Roth, N., Scharl, Michael; https://orcid.org/, Vavricka, S.R., Scharl, M., Swiss IBD Cohort Study Group, Biedermann, Luc, Stephan R Vavricka, Swiss IBD Cohort Study Group,, Biedermann, L., Butter, Matthias, Alexander A Navarini, Navarini, Alexander A, Matthias Butter, Fournier, N., Roth, Nina, Fournier, Nicolas, Gerhard Rogler, Scharl, Michael, Nina Roth, Michael Scharl, Vavricka, Stephan R, Navarini, Alexander A.   +28 more
core   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease

, 2011
BACKGROUND: The diagnosis of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), continues to present difficulties due to unspecific symptoms and limited test accuracies.
Alex Straumann, Braegger, C P, Michetti, P, Braegger, C.P., Straumann, A, Valérie Pittet, Fried, M., Bauerfeind, P., Rogler, G., Peter Bauerfeind, Schoepfer, A M, Daniela Rogler, Vavricka, S.R., Christian Mottet, Stephan R. Vavricka, Felley, C., Felley, C, Pittet, V, Michael Fried, Mottet, C., Spigaglia, S.M., Christian P. Braegger, Alain M. Schoepfer, Pittet, V., Sabrina M. Spigaglia, Gerhard Rogler, Rogler, D., Spigaglia, S M, Schoepfer, A.M., Vavricka, S R, Michetti, P., Christian Felley, Bauerfeind, P, Rogler, G, Straumann, A., Pierre Michetti, Mottet, C, Rogler, D, Fried, M   +38 more
core   +1 more source

Change of treatment modalities over the last 10 years in pediatric patients with inflammatory bowel disease in Switzerland [PDF]

, 2018
BACKGROUND AND AIM During the past decade, several new drugs were approved for the treatment of pediatric inflammatory bowel disease (IBD). We aimed to evaluate if and how pharmacologic treatment options for pediatric IBD in Switzerland have changed ...
Spalinger, J., Schibli, S., Nydegger, A., Guilcher, K., Spalinger, Johannes, Braegger, C., Fournier, N., Fournier, Nicolas, Schoepfer, A., Braegger, Christian, Schoepfer, Alain, Guilcher, Katharina, Schibli, Susanne, Swiss IBD Cohort Study Group, Nydegger, Andreas   +14 more
core   +2 more sources

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source