Results 51 to 60 of about 145,684 (315)

Insight Report: Online public involvement session on the views of patients living with Inflammatory Bowel Disease (IBD) in relation to a Multiomic phenotyping of IBD. [PDF]

, 2022
A report summarising the insights of patients living with IBD about an Imperial BRC research project involving Multiomic phenotyping of ...
Perry, robert, Balarajah, Sharmili, Piggin, Maria   +2 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease

, 2011
BACKGROUND: The diagnosis of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), continues to present difficulties due to unspecific symptoms and limited test accuracies.
Alex Straumann, Braegger, C P, Michetti, P, Braegger, C.P., Straumann, A, Valérie Pittet, Fried, M., Bauerfeind, P., Rogler, G., Peter Bauerfeind, Schoepfer, A M, Daniela Rogler, Vavricka, S.R., Christian Mottet, Stephan R. Vavricka, Felley, C., Felley, C, Pittet, V, Michael Fried, Mottet, C., Spigaglia, S.M., Christian P. Braegger, Alain M. Schoepfer, Pittet, V., Sabrina M. Spigaglia, Gerhard Rogler, Rogler, D., Spigaglia, S M, Schoepfer, A.M., Vavricka, S R, Michetti, P., Christian Felley, Bauerfeind, P, Rogler, G, Straumann, A., Pierre Michetti, Mottet, C, Rogler, D, Fried, M   +38 more
core   +1 more source

Change of treatment modalities over the last 10 years in pediatric patients with inflammatory bowel disease in Switzerland [PDF]

, 2018
BACKGROUND AND AIM During the past decade, several new drugs were approved for the treatment of pediatric inflammatory bowel disease (IBD). We aimed to evaluate if and how pharmacologic treatment options for pediatric IBD in Switzerland have changed ...
Spalinger, J., Schibli, S., Nydegger, A., Guilcher, K., Spalinger, Johannes, Braegger, C., Fournier, N., Fournier, Nicolas, Schoepfer, A., Braegger, Christian, Schoepfer, Alain, Guilcher, Katharina, Schibli, Susanne, Swiss IBD Cohort Study Group, Nydegger, Andreas   +14 more
core   +1 more source

Additional file 1 of Objective disease activity assessment and therapeutic drug monitoring prior to biologic therapy changes in routine inflammatory bowel disease clinical practice: TARGET-IBD

, 2022
Additional file 1: Table 1a. TARGET-IBD Labs/Imaging 24 Weeks Prior to Dose Changes of Biologic Therapy Due to Lack of Effect. Table 1b. TARGET-IBD Labs/Imaging 24 Weeks Prior to Discontinuations of Biologic Therapy Due to Lack of Effect.
Marla C. Dubinsky (10978320), Edward L. Barnes (12109440), John S. Hanson (12109446), Miguel Regueiro (12109449), Derek Gazis (12109452), Julie M. Crawford (12109455), Benjamin L. Cohen (12109443), David T. Rubin (3376760), Millie D. Long (12109458), Benjamin Click (12109437), Bruce E. Sands (9710836)   +10 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Challenges in IBD Research: Preclinical Human IBD Mechanisms [PDF]

Inflammatory Bowel Diseases, 2019
Preclinical human IBD mechanisms is part of five focus areas of the Challenges in IBD research document, which also include environmental triggers, novel technologies, precision medicine and pragmatic clinical research. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD ...
Pizarro, Theresa T., Stappenbeck, Thaddeus S., Rieder, Florian, Rosen, Michael J., Colombel, Jean-Frédéric, Donowitz, Mark, Towne, Jennifer, Mazmanian, Sarkis K., Faith, Jeremiah J., Hodin, Richard A., Garrett, Wendy S., Fichera, Alessandro, Poritz, Lisa S., Cortes, Constanza J., Shtraizent, Nataly, Honig, Gerard, Snapper, Scott B., Hurtado-Lorenzo, Andrés, Salzman, Nita H., Chang, Eugene B.   +19 more
openaire   +3 more sources

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study [PDF]

, 2019
BACKGROUND/AIMS Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS)
Rogler, Gerhard, Nicolas Fournier, Vavricka, Stephan R., Rogler, G., Butter, M., Navarini, A.A., Luc Biedermann, Roth, N., Scharl, Michael; https://orcid.org/, Vavricka, S.R., Scharl, M., Swiss IBD Cohort Study Group, Biedermann, Luc, Stephan R Vavricka, Swiss IBD Cohort Study Group,, Biedermann, L., Butter, Matthias, Alexander A Navarini, Navarini, Alexander A, Matthias Butter, Fournier, N., Roth, Nina, Fournier, Nicolas, Gerhard Rogler, Scharl, Michael, Nina Roth, Michael Scharl, Vavricka, Stephan R, Navarini, Alexander A.   +28 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Efficacy and Safety of Switching From Intravenous to Subcutaneous Vedolizumab in Japanese Patients With Ulcerative Colitis: A Study Focusing on Injection‐Site Reactions

JGH Open
Background/Aims The subcutaneous (SC) formulation of vedolizumab is available as an alternative to the intravenous (IV) formulation in patients with ulcerative colitis (UC).
Makoto Furuya, Kiichiro Yoza, Takeshi Yonezawa, Ken Takeuchi   +3 more
doaj   +1 more source