Results 31 to 40 of about 108,837 (264)

Randomized controlled pilot study: effect of carrageenan emulsifier on inflammation and gastrointestinal symptoms in quiescent ulcerative colitis

Food & Nutrition Research, 2023
Background: Animal models have provided some evidence of the pro-inflammatory effects of the commonly used emulsifier carrageenan. However, the effects of food-grade carrageenan among people with ulcerative colitis (UC) are largely unknown.
Reijo Laatikainen, Markku Lehto, Noora Mäkelä-Salmi, Markku Hillilä, Per-Henrik Groop, Hanne Salmenkari   +5 more
doaj   +1 more source

How IBD patients cope with IBD: A systematic review [PDF]

Journal of Crohn's and Colitis, 2013
Inflammatory bowel disease (IBD) can have a significant impact on psychological wellbeing and quality of life. How one responds to and copes with IBD may be an important determinant of psychological wellbeing. We aimed to systematically review all published literature regarding coping strategies of IBD patients.Ovid and Pubmed databases were searched ...
McCombie, Andrew M., Mulder, Roger T., Gearry, Richard B.   +2 more
openaire   +2 more sources

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Propagation, Purification and Molecular Characterization of RVF virus (ZH 501) Strain for Vaccine Production in Egyptt

Journal of Applied Veterinary Sciences, 2019
Rift Valley Fever (RVF) is an endemic disease in Egypt causing disease in animals and humans since the 1977. Full molecular description of the national vaccine strain is a strategic concern to ensure the antigenic makeup of local vaccine is adequate to ...
Abo Hatab E. M., M. H. Ali, Atwa, M. H., Abul Magd, D.M., Ahmed F. Soudy, Saad A. Moussa   +5 more
doaj   +1 more source

Current trends and future perspectives of natural polymer loaded nanoparticle based drug delivery system for the management of inflammatory bowel disease

Journal of Applied Pharmaceutical Research, 2023
Targeting the drug delivery system is very tough nowadays due to premature drug release at the upper GIT tract and altered pH conditions. Colon-specific drug delivery systems can overcome that problem using different polymer combinations.
Ankita Basak, Soumyadip Ghosh, Debgopal Ganguly, Soukat Garain, Riya Ghosh, Ananta Choudhury, Himangshu Deka, Jahnabi Sarmah   +7 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Challenges in IBD Research: Preclinical Human IBD Mechanisms [PDF]

Inflammatory Bowel Diseases, 2019
Preclinical human IBD mechanisms is part of five focus areas of the Challenges in IBD research document, which also include environmental triggers, novel technologies, precision medicine and pragmatic clinical research. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD ...
Pizarro, Theresa T., Stappenbeck, Thaddeus S., Rieder, Florian, Rosen, Michael J., Colombel, Jean-Frédéric, Donowitz, Mark, Towne, Jennifer, Mazmanian, Sarkis K., Faith, Jeremiah J., Hodin, Richard A., Garrett, Wendy S., Fichera, Alessandro, Poritz, Lisa S., Cortes, Constanza J., Shtraizent, Nataly, Honig, Gerard, Snapper, Scott B., Hurtado-Lorenzo, Andrés, Salzman, Nita H., Chang, Eugene B.   +19 more
openaire   +3 more sources

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Efficacy and Safety of Switching From Intravenous to Subcutaneous Vedolizumab in Japanese Patients With Ulcerative Colitis: A Study Focusing on Injection‐Site Reactions

JGH Open
Background/Aims The subcutaneous (SC) formulation of vedolizumab is available as an alternative to the intravenous (IV) formulation in patients with ulcerative colitis (UC).
Makoto Furuya, Kiichiro Yoza, Takeshi Yonezawa, Ken Takeuchi   +3 more
doaj   +1 more source