Beyond FoxP3—Identification of a Chicken Regulatory T Cell Signature
European Journal of Immunology, Volume 55, Issue 12, December 2025.Chicken FOXP3+ putative regulatory T cells were identified using both bulk and single‐cell RNA sequencing to define their transcriptional signature and flow cytometry to confirm surface marker expression. This combined approach revealed a distinct putative Treg subset characterized by CD4, CD25, and GITR surface expression. ABSTRACT Regulatory T cells (
Isabell Naumann +9 more
wiley +1 more source
Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa [PDF]
, 2006 Little is understood about the immune responses involved in the pathogenesis of infectious bursal disease virus (IBDV). Strains of IBDV differ in their virulence: F52/70 is a classical virulent strain (vIBDV), whereas UK661 is a very virulent strain ...
Balu, Sucharitha +6 more
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Yeast, Volume 42, Issue 12, Page 303-310, December 2025.ABSTRACT Yeasts have been intimately connected with human civilization for millennia, originally used for fermentation in food and beverage production. This article explores the multifaceted roles of yeasts—particularly Saccharomyces cerevisiae—as both a model organism and a cell factory.
Jens Nielsen
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A preventive cytokine treatment of the viral infectious bursal disease (IBD) of chickens [PDF]
, 2015 Infectious bursal disease (IBD) is a viral disease of young chickens that produce severe lesions in the bursa of Fabricius and other organs inducing immunosuppression and mortality in birds. This study indicates that oral administration of IFN-α and IL-2
D'Ambrosio, Elisa +7 more
core +1 more source
Viruses, 2023 Gumboro illness is caused by the highly contagious immunosuppressive infectious bursal disease virus (IBDV), which affects the poultry industry globally.
Yesica R. Frontini-López +6 more
doaj +1 more source
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
Immunology, Volume 176, Issue 3, Page 277-303, November 2025.The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder +4 more
wiley +1 more source
Molecular and Biological Characterization of Two Very Virulent Infectious Bursal Disease Virus Isolates, Upm94/273 and Upm97/61 [PDF]
, 2003 An atypical very virulent (w) strain (UPM94/273) and typical vv strain (UPM97/61) of infectious bursal disease virus (IBOV) isolated in Malaysia, were characterized both in vivo and at the molecular level.
Kong , Lih Ling
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The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Advanced Science, Volume 12, Issue 33, September 4, 2025.The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu +17 more
wiley +1 more source
PROTECTION ACTIVITY OF T CELL LYMPHOKINES AGAINST INFECTIOUS BURSAL DISEASE IN LAYER PULLETS
The Iraqi Journal of Agricultural science, 2023 The present study was aimed to administering hyperimmunized avian salmonella-immune lymphokines (S-ILK) to 200 one-day-old layer pullets to improve the immunological response against Gumboro (IBDV) divided into four groups.
Mushtaq T. B. Al-Zuhariy
doaj +1 more source
Development of reverse genetics systems for infectious bursal disease virus by yeast-based homologous recombination. [PDF]
, 2013 Projeto/Plano de Ação: 05.11.10.200 ...
ARENHART, S. +4 more
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