The serotonin receptor 3E variant is a risk factor for female IBS-D [PDF]
Journal of Molecular Medicine, 2022 AbstractIrritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular.
Beate Niesler +2 more
exaly +15 more sources
Multiomics Analysis Reveals Gut Virome–Bacteria–Metabolite Interactions and Their Associations with Symptoms in Patients with IBS-D [PDF]
VirusesThe gut microbiota is involved in the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), but few studies have focused on the role of the gut virome in IBS-D.
Peiwei Xie +3 more
doaj +3 more sources
Impact of symptom severity in patients with diarrhoea-predominant irritable bowel syndrome (IBS-D): results from two separate surveys of HCPs and patients with IBS-D [PDF]
BMC Gastroenterology, 2020 Background Management of diarrhoea-predominant irritable bowel syndrome (IBS-D) is generally based on patient-reported symptoms; however, limited information on symptom severity exists.
Anton Emmanuel +4 more
doaj +5 more sources
Nutrients, 2021 Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits.
Annamaria Altomare +2 more
exaly +2 more sources
Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1. [PDF]
Cells, 2023 Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies.
Awad K +7 more
europepmc +2 more sources
Altered gut microbiota-host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern. [PDF]
Chin Med, 2023 Background Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional Chinese Medicine (TCM), instructed by pattern differentiation, is effective
Du L +9 more
europepmc +2 more sources
Integrated omics analysis reveals the epigenetic mechanism of visceral hypersensitivity in IBS-D. [PDF]
Front Pharmacol, 2023 Background and objective: IBS-D is a common functional bowel disease with complex etiology and without biomarker. The pathological and physiological basis of IBS-D focuses on visceral hypersensitivity.
Lu Y +7 more
europepmc +2 more sources
The characteristics of intestinal flora of IBS‐D with different syndromes [PDF]
Immunity, Inflammation and Disease, 2020 AbstractObjectiveTo study the distribution of fecal microbiota in diarrhea‐predominant irritable bowel syndrome (IBS‐D) patients of spleen–kidney‐yang deficiency and liver depression and spleen deficiency, to make an objective foundation for dialectics of different type of IBS‐D.
Guanqun Chao, Shuo Zhang
openaire +4 more sources
Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model. [PDF]
Gut Microbes, 2023 Diarrhea-predominant irritable bowel syndrome (IBS-D), associated with increased intestinal permeability, inflammation, and small intestinal bacterial overgrowth, can be triggered by acute gastroenteritis. Cytolethal distending toxin B (CdtB) is produced
Leite G +12 more
europepmc +2 more sources
Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism. [PDF]
Front NutrBackground The pathophysiological mechanisms of irritable bowel syndrome (IBS) are intricate, and associated with tryptophan metabolites. This study was designed to investigate the relationship between indole metabolites in the feces and intestinal ...
Wang L +10 more
europepmc +2 more sources