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Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate [PDF]
Molecules, 2015 In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility.
Kitak, Teja +4 more
exaly +5 more sources
Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments
Microorganisms, 2020 Ibuprofen, a non-steroidal anti-inflammatory pain reliever, is among pharmaceutical residues of environmental concern ubiquitously detected in wastewater effluents and receiving rivers.
Cyrus Rutere +4 more
doaj +2 more sources
Hydrolysis of Ibuprofen Nitrile and Ibuprofen Amide and Deracemisation of Ibuprofen Using Nocardia corallina B-276 [PDF]
Molecules, 2012 A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells
Myrna Solís-Oba +4 more
doaj +3 more sources
Safety of ibuprofen in infants younger than six months: A retrospective cohort study. [PDF]
PLoS ONE, 2018 OBJECTIVE:We hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse ...
Paul Walsh +2 more
doaj +5 more sources
In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel [PDF]
Pharmaciana, 2021 The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. The inclusion complex is formed by utilizing b-cyclodextrin as the host of the active compounds.
Fitrianti Darusman +4 more
doaj +1 more source
Effect of the type of amino acid on the biodegradation of ibuprofen derivatives [PDF]
Archives of Environmental Protection, 2023 Water pollution caused by anthropogenic activity is a huge environmental problem. Huge amounts of consumed medicinal substances cause them to get into the environment.
Paula Elżbieta Ossowicz-Rupniewska +5 more
doaj +1 more source
Pain and Therapy, 2020 Introduction Ibuprofen acid is poorly soluble in the stomach, thus reaching maximum plasma levels at approximately 90 min post-dose. Ibuprofen lysinate has been developed to accelerate absorption of ibuprofen to shorten the time to analgesic efficacy ...
Ján Kyselovič +3 more
doaj +1 more source
Scientific Reports, 2021 Over the last decade oxylipins have become more recognized for their involvement in several diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to inhibit cyclooxygenase (COX) enzymes, but how NSAIDs affect oxylipins, in ...
Shuchita Tiwari +5 more
doaj +1 more source
Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans. [PDF]
, 2016 Ventilatory acclimatization to hypoxia is a time-dependent increase in ventilation and the hypoxic ventilatory response (HVR) that involves neural plasticity in both carotid body chemoreceptors and brainstem respiratory centers.
Antonova, Julie +7 more
core +2 more sources