Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance [PDF]
RSC Advances, 2015 Ibuprofen exhibits poor flow, poor compaction and dissolution behaviour, and it is prone to capping after ejection from the die. Therefore, the aim of the present research was to engineer ibuprofen crystals in the presence of two disintegrants (starch ...
Ali Nokhodchi +5 more
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Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate [PDF]
Molecules, 2015 In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility.
Odon Planinšek, Rok Šibanc
exaly +4 more sources
In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel [PDF]
Pharmaciana, 2021 The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. The inclusion complex is formed by utilizing b-cyclodextrin as the host of the active compounds.
Fitrianti Darusman +4 more
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Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
Clinical Pharmacology: Advances and Applications, 2014 Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal ...
Pacifici GM
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Ibuprofen Degradation and Associated Bacterial Communities in Hyporheic Zone Sediments
Microorganisms, 2020 Ibuprofen, a non-steroidal anti-inflammatory pain reliever, is among pharmaceutical residues of environmental concern ubiquitously detected in wastewater effluents and receiving rivers.
Cyrus Rutere +4 more
doaj +1 more source
Effect of the type of amino acid on the biodegradation of ibuprofen derivatives [PDF]
Archives of Environmental Protection, 2023 Water pollution caused by anthropogenic activity is a huge environmental problem. Huge amounts of consumed medicinal substances cause them to get into the environment.
Paula Elżbieta Ossowicz-Rupniewska +5 more
doaj +1 more source
Safety of ibuprofen in infants younger than six months: A retrospective cohort study. [PDF]
PLoS ONE, 2018 OBJECTIVE:We hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse ...
Paul Walsh +2 more
doaj +1 more source
Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. [PDF]
, 2006 The aim of this study is to develop a once-daily sustained release matrix tablet of ibuprofen using hydroxypropyl methylcellulose (HPMC) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order
Tazeen, Jaweria +3 more
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Ibuprofen and sila-ibuprofen: polarization effects in the crystal and enzyme environments [PDF]
, 2021 Sila-ibuprofen is a new potential nonsteroidal anti-inflammatory drug which deviates from its parent ibuprofen in terms of the electrostatic potential around the carbon/silicon-switched C/Si—H group.
Kleemiss, Florian +6 more
core +2 more sources
Pain and Therapy, 2020 Introduction Ibuprofen acid is poorly soluble in the stomach, thus reaching maximum plasma levels at approximately 90 min post-dose. Ibuprofen lysinate has been developed to accelerate absorption of ibuprofen to shorten the time to analgesic efficacy ...
Ján Kyselovič +3 more
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