Results 161 to 170 of about 27,302,336 (342)

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells

iMeta, EarlyView.
The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non‐invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, their rarity and heterogeneity limit conventional tumor antigen labelling‐based methods in identifying and tracing CTCs.
Bin Ye, Zhen Wang, Yinqi Bai, Xu Zhang, Rui Zhang, Jingru Lian, Xuefei Liu, Yan Zhang, Zhiyuan Xu, Li Yang, Haiman Jin, Fang Chen, Zhihao Xie, Ping Zhou, Jun Tan, Shan Zeng, Changzheng Du, Yang Min, Xiaomin Ni, Jingxian Duan, Zhicheng Li, Hui Yang, Yunpeng Cai, Hongyan Wu, Catherine C. Liu, Jing Cai, Yi Lu, Jian Zhang, Hao Wu, Hairong Zheng, Longqi Liu, Xin Hong, Hao Yu   +32 more
wiley   +1 more source

PENGARUH HEMODIALISIS TERHADAP KADAR IL - 1β DAN ICAM - 1 PADA PASIEN PENYAKIT GINJAL KRONIS STADIUM V [PDF]

, 2010
Di Indonesia Penyakit Ginjal Kronik (PGK) merupakan penyakit yang banyak dijumpai dan mencapai 29,1 % dari populasi dengan berbagai faktor risiko (hipertensi, diabetes, proteinuria). Prevalensi pasien PGK diperkirakan akan semakin meningkat.
SUSANTO, AGUNG
core  

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain

Interdisciplinary Medicine, EarlyView.
A fully characterised organ‐on‐a‐chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successfully recapitulates the physiological effects of pulsatile vessel dilation on cell morphology and the localised inflammatory susceptibility to TNF‐α ...
Yu Hou, Georgios Ziakas, Tim Hopkins, Wen Wang, Hazel R. C. Screen, Martin M. Knight   +5 more
wiley   +1 more source

短发夹RNA对肝癌细胞细胞间粘附分子-1基因表达的影响

Zhongguo shiyan zhenduanxue, 2006
目的利用小片段干扰RNA（siRNA）在肝癌细胞内诱导RNA干扰（RNAi）,抑制细胞间粘附分子-1（ICAM-1）基因表达,在体外进行RNAi对肝癌治疗的实验研究。方法根据ICAM-1基因设计shRNA片断,构建pGenesil-1/ICAM-1表达载体,转入E.coli菌,并用Lipofectamine tm2000转染HepG2细胞,通过MTT方法检测细胞活性状态,应用免疫组织化学的方法检测肝癌细胞中ICAM-1基因蛋白质表达抑制情况。结果本实验已成功构建了针对ICAM-1基因的pGenesil ...
廖维甲, 梅铭惠, 覃理灵, 向秋, 徐静, 范才文   +5 more
doaj  

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source