Results 181 to 190 of about 85,965 (264)

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

open access: yesGlia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat   +3 more
wiley   +1 more source

Mesenteric Lymphatic Dysfunction as the Initiating Event in Crohn's Disease: Toward an Outside‐In Paradigm

open access: yesJCC Plus, Volume 1, Issue 4, July 2026.
Mesenteric lymphatic dysfunction promotes immune cell accumulation and chronic inflammation, leading to creeping fat formation. Progressive activity drives transmural inflammation. ABSTRACT Crohn's disease (CD) has traditionally been explained by an “inside‐out” model, in which disruption of the intestinal mucosal barrier allows luminal bacteria to ...
Takayuki Ogino   +9 more
wiley   +1 more source

sVCAM‐1 and Hematological Profiles Are Associated With CD4‐Defined Disease Status in HIV Infection

open access: yesJournal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Brazil stands out for its progressive public health policies against HIV, including universal access to antiretroviral therapy and a stricter AIDS definition (CD4 < 350 cells/mm3) compared to the World Health Organization (WHO) criterion (CD4 ≤ 200 cells/mm3).
Bruno Almeida‐Silva   +8 more
wiley   +1 more source

VCL/ICAM-1 pathway is associated with lung inflammatory damage in SARS-CoV-2 Omicron infection. [PDF]

open access: yesNat Commun
Xue M   +27 more
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An   +4 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen   +6 more
wiley   +1 more source

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