Results 161 to 170 of about 85,965 (264)

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Midlife ICAM-1 levels may predict cardiovascular disease and cognitive decline in latelife: Insights from the HeartSCORE study. [PDF]

Atheroscler Plus
Abdoun K, Swanson J, Pollack I, Chang Y, Kip K, Lopez OL, Cohen A, Reis S, Saeed A.   +8 more
europepmc   +1 more source

Mitochondrial peptide MOTS‐c suppresses systemic and cardiac inflammasome activation in a diabetic rat model

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial‐derived peptide mitochondrial open reading frame of the 12S rRNA type‐C (MOTS‐c) has emerged as a promising regulator of metabolic and inflammatory pathways.
Aimee R. Mills, Antonio de Souza, Toan Pham, Odunayo O. Mugisho   +3 more
wiley   +1 more source

ICAM-1 autoantibodies detected in healthy individuals and cross-react with functional epitopes. [PDF]

Immunohorizons
Herman ML, Geanes ES, McLennan R, Greening GJ, Mwitanti H, Bradley T.   +5 more
europepmc   +1 more source

Angiotensin II promotes ICAM-1 expression in vitro and soluble ICAM-1 secretion in vivo [PDF]

American Journal of Hypertension, 1998
openaire   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

ICAM-1-mediated Src signaling pathway plays a pivotal role in encephalomyocarditis virus entry. [PDF]

J Virol
Lian R, Dou X, Wang N, Li S, Xie J, Li X, Yang Y, Wen Y, Li H, Feng R.   +9 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression. [PDF]

Front Cell Dev Biol
Lin J, Fourcade L, Roussel L, Marabella M, Bérubé J, Nguyen D, Rousseau S.   +6 more
europepmc   +1 more source

Expression of ICAM-1 and Soluble ICAM-1 in the Circulation and BALF of Patients with Sarcoidosis

NIHON SARUKOIDOSHISU GAKKAI ZASSHI (The Japanese journal of sarcoidosis), 1994
openaire   +1 more source