Results 271 to 280 of about 27,302,336 (342)

Three‐dimensional patient‐derived endometriosis model for drug evaluation

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 629-646, April 2026.
In this study, we developed a coculturing model with stromal cells and epithelial organoids to mimic the endometriotic lesion and for further evaluation of drug effects. Abstract Introduction Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms.
Yuqi Li, Wei Shao, Xiaoxiao Gao, Yongxing Wang, Jinzhi Li, Liansuo Zhang, Yanyan Xing, Wentao Su, Yan Cheng, Li Wang, Songping Liu   +10 more
wiley   +1 more source

Correction: ICAM-1 and CRP as biomarkers of 3-month outcome in acute ischaemic stroke. [PDF]

BMJ Neurol Open
europepmc   +1 more source

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson's Disease. [PDF]

Cells
Miller MR, Landis HE, Miller RE, Tizabi Y.   +3 more
europepmc   +1 more source

Interactive online calculator for estimation of muscle and hepatic insulin sensitivity in adults with Type 1 diabetes using clinical and research biomarkers

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3238-3244, April 2026.
Abstract Aims Impaired insulin sensitivity is an under‐recognised risk in Type 1 diabetes but is challenging to measure with ‘gold‐standard’ euglycaemic clamps. Adding stable‐isotope glucose distinguishes hepatic and muscle insulin action (assessed by endogenous glucose production [EGP] and glucose infusion rate [GIR], respectively).
Andrzej S. Januszewski, Jennifer R. Snaith, Greg M. Kowalski, Clinton R. Bruce, D. Jane Holmes‐Walker, Alicia J. Jenkins, Jerry R. Greenfield   +6 more
wiley   +1 more source

New Cellular Models to Support Preclinical Studies on ICAM-1-Targeted Drug Delivery. [PDF]

J Drug Deliv Sci Technol
Vigo M, Haro-Martínez E, Ruiz E, Fumadó-Navarro J, Placci M, Muro S.   +5 more
europepmc   +1 more source

Aerobic Exercise Ameliorates Adverse Vascular Remodeling in Diabetes via PDK1/FoxO1 Axis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Reduced PDK1 expression in the carotid arteries of type 1 diabetic mice promotes abnormal FoxO1 expression, thereby inducing inflammatory responses and vascular remodeling. These phenotypes can be ameliorated by regular aerobic exercise. In vitro experiments further confirm that the PDK1‐FoxO1 signaling axis in a high‐glucose environment can induce ...
Xiang Xie, Zihan Zhang, Xumei Yang, Man Chu   +3 more
wiley   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

DNA Methyltransferase Inhibition Upregulates the Costimulatory Molecule ICAM-1 and the Immunogenic Phenotype of Melanoma Cells. [PDF]

JID Innov
Cereghetti ASP, Turko P, Cheng P, Benke S, Al Hrout A, Dzung A, Dummer R, Hottiger MO, Chahwan R, Ferretti LP, Levesque MP.   +10 more
europepmc   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

<i>Veillonella parvula</i> outer membrane vesicles increase ICAM-1⁺ neutrophils exhibiting elevated NET formation via ROS-PAD4 signaling. [PDF]

Front Cell Infect Microbiol
Xu L, Jiang Y, Zhao X, Zhuang J, Chen H, Li T, He Z, Zhou W, Song Z.   +8 more
europepmc   +1 more source