Integrated framework for tirzepatide in HFpEF management. Through metabolic, haemodynamic, structural and anti‐inflammatory pathways, tirzepatide modifies the disease trajectory of HFpEF, leading to improvements in symptoms, functional capacity and reduction in HF events.
Hamza A. Abdul‐Hafez +9 more
wiley +1 more source
Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley +1 more source
Human rhinovirus 16 induces an ICAM-1-PKR-ATF2 axis to modulate macrophage functions. [PDF]
Faure-Dupuy S +4 more
europepmc +1 more source
Recent Advances in the Bioactive Compounds of Prunes (Prunus domestica L.) and Their Health Benefits
Prunes (Prunus domestica L.) are a functional food rich in diverse bioactive compounds, including polyphenols (such as chlorogenic acid and anthocyanins), polysaccharides, and sorbitol.This review comprehensively synthesizes current research on the nutritional composition and biological activities of prunes, highlighting their multifaceted health ...
Luyang Han +10 more
wiley +1 more source
Альтернативные формы мРНК ICAM-1 и растворимый ICAM-1 у больных раком почки
openaire +1 more source
ABSTRACT Background and Aims Asthma is a chronic respiratory disorder with both genetic and environmental underlying risk factors. Allergic asthma, the most prevalent kind, is mostly ascribed to aberrant T helper type 2 (Th2) inflammation and is brought on by allergens.
Ayenew Assefa +2 more
wiley +1 more source
Inhibition of Mac-1 allows human macrophages to migrate against the direction of shear flow on ICAM-1. [PDF]
Mittal A +4 more
europepmc +1 more source
Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira +10 more
wiley +1 more source
Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR. [PDF]
Kang JH +13 more
europepmc +1 more source
A novel form of integrin dysfunction involving beta 1, beta 2, and beta 3 integrins [PDF]
Hogg, N +6 more
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