Results 51 to 60 of about 27,302,336 (342)

Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent

Journal of Nanobiotechnology, 2012
Background The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothelium of blood vessels in response to pro-inflammatory stimuli is of major importance for the regulation of local inflammation in cardiovascular diseases such as ...
Paulis Leonie EM, Jacobs Igor, van den Akker Nynke M, Geelen Tessa, Molin Daniel G, Starmans Lucas WE, Nicolay Klaas, Strijkers Gustav J   +7 more
doaj   +1 more source

ICAM-1 receptors and cold viruses

Pharmaceutica Acta Helvetiae, 2000
Human rhinoviruses (HRVs), the single most important etiologic agent of common colds, are small viruses composed of an icosahedral protein shell that encapsidates a single, positive RNA strand. Multiplication of HRVs occurs in the cytoplasm of the host cell.
Bella, Jordi, Rossmann, Michael G.
openaire   +2 more sources

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

Scientific Reports, 2017
Adoptive transfer of high-affinity chimeric antigen receptor (CAR) T cells targeting hematological cancers has yielded impressive clinical results. However, safety concerns regarding target expression on healthy tissue and poor efficacy have hampered ...
Spencer Park, E. Shevlin, Y. Vedvyas, M. Zaman, Susan Park, Yen-Michael S. Hsu, I. Min, Moonsoo M. Jin   +7 more
semanticscholar   +1 more source

Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria [PDF]

, 2017
The adhesion of malaria infected red blood cells (iRBCs) to host endothelial receptors in the microvasculature, or cytoadhesion, is associated with severe disease pathology such as multiple organ failure and cerebral malaria.
Cao, Jianshu, Lim, Chwee-Teck, Lim, Ying Bena, Thingna, Juzar   +3 more
core   +1 more source

Induction of osteoclast-like cell formation by leptin-induced soluble intercellular adhesion molecule secreted from cancer cells

Therapeutic Advances in Medical Oncology, 2019
Background: Leptin is considered a tumorigenic adipokine, suggested to promote tumorigenesis and progression in many cancers. On the other hand, intercellular adhesion molecule-1 (ICAM-1) shows altered expression in a variety of benign and malignant ...
Cheng-Fang Tsai, Jia-Hong Chen, Chen-Teng Wu, Pei-Chun Chang, Shu-Lin Wang, Wei-Lan Yeh   +5 more
doaj   +1 more source

ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer

Cell Death and Disease, 2022
Colorectal cancer (CRC) has a 5-year survival rate of
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee   +4 more
doaj   +1 more source

LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease

Journal of Ocular Pharmacology and Therapeutics, 2017
Dry eye disease (DED) is a common ocular disorder associated with inflammation of the lacrimal gland and ocular surface. The interaction of the integrin lymphocyte function-associated antigen-1 (LFA-1) with its cognate ligand intercellular adhesion ...
S. Pflugfelder, M. Stern, Steven Zhang, Amir H. Shojaei   +3 more
semanticscholar   +1 more source

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source

ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, the molecular events in the HSC niche remain to be investigated. Here, we report that
Yu-feng Liu, Shao-ying Zhang, Ying-ying Chen, Kun Shi, Bin Zou, Jun Liu, Qiong Yang, Hua Jiang, Lai Wei, Chang-zheng Li, Meng Zhao, Dmitry I. Gabrilovich, Hui Zhang, Jie Zhou   +13 more
doaj   +1 more source

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice [PDF]

, 2009
Background: Pancreatic infiltration by leucocytes represents a hallmark in acute pancreatitis. Although leucocytes play an active role in the pathophysiology of this disease, the relation between leucocyte activation, microvascular injury and haemorrhage
Deduchovas, O., Hartwig, W., Kerkadze, V., Märten, A., Parseliunas, A., Ryschich, E., Salnikova, O., Schmidt, J., Sperandio, Markus   +8 more
core   +1 more source