Results 51 to 60 of about 159,080 (332)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reduction of Endothelial Nitric Oxide Increases the Adhesiveness of Constitutive Endothelial Membrane ICAM-1 through Src-Mediated Phosphorylation

Frontiers in Physiology, 2018
Nitric oxide (NO) is a known anti-adhesive molecule that prevents platelet aggregation and leukocyte adhesion to endothelial cells (ECs). The mechanism has been attributed to its role in the regulation of adhesion molecules on leukocytes and the adhesive
Feng Gao, Brandon P. Lucke-Wold, Brandon P. Lucke-Wold, Xiang Li, Aric F. Logsdon, Aric F. Logsdon, Li-Chong Xu, Sulei Xu, Kyle B. LaPenna, Huaqi Wang, Huaqi Wang, M. A. Hassan Talukder, Christopher A. Siedlecki, Jason D. Huber, Charles L. Rosen, Pingnian He   +15 more
doaj   +1 more source

ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

Cells, 2021
To efficiently cross the endothelial barrier during inflammation, neutrophils first firmly adhere to the endothelial surface using the endothelial adhesion molecule ICAM-1. Upon actual transmigration, the release from ICAM-1 is required.
Sofia K. H. Morsing, Timo Rademakers, Sanne L. N. Brouns, Anne-Marieke D. van Stalborch, Marjo M. P. C. Donners, Jaap D. van Buul   +5 more
doaj   +1 more source

Increased ICAM-1 expression in aortic disease [PDF]

Journal of Vascular Surgery, 1993
In this investigation we evaluated the expression of vascular adhesion molecules: intercellular adhesion molecule-1 (ICAM-1), E-selectin, and vascular cell adhesion molecule-1 (VCAM-1) in normal and diseased aorta.Aortic tissue was obtained during operations for abdominal aortic aneurysms (AAA) (inflammatory, n = 3, noninflammatory, n = 6), aortic ...
C A, Davis, W H, Pearce, G K, Haines, M, Shah, A E, Koch   +4 more
openaire   +2 more sources

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J., Harrow, C., Lees, K.R., Muir, S.W., Sattar, N., Walters, M.R., Weir, C.J.   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ICAM-1 Antisense Oligodeoxynucleotide Improves Islet Allograft Survival and Function

Cell Transplantation, 2000
Expression of intercellular adhesion molecule-1 (ICAM-1) and its ligand, leukocyte function antigen-1 (LFA-1), after pancreatic islet transplantation may affect both nonspecific and alloantigen-specific phases of graft destruction.
Stephen M. Katz M.D., Frank Bennett, Kim Stecker, James H. Clark, Tommy Phan, Mou-Er Wang, Barry D. Kahan, Stanislaw M. Stepkowski   +7 more
doaj   +1 more source

Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda

Malaria Journal, 2010
Background Intercellular adhesion molecule-1 (ICAM-1) is a cytoadhesion molecule implicated in the pathogenesis of Plasmodium falciparum malaria. Elevated levels of soluble ICAM-1 (sICAM-1) have previously been reported with increased malaria disease ...
Cserti-Gazdewich Christine M, Dzik Walter H, Erdman Laura, Ssewanyana Isaac, Dhabangi Aggrey, Musoke Charles, Kain Kevin C   +6 more
doaj   +1 more source

ICAMs are dispensable for influenza clearance and anti-viral humoral and cellular immunity

Frontiers in Immunology, 2023
αLβ2 (LFA-1) mediated interactions with ICAM-1 and ICAM-2 predominate leukocyte-vascular interactions, but their functions in extravascular cell-cell communications is still debated.
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon   +13 more
doaj   +1 more source

Autophagy facilitates cytokine-induced ICAM-1 expression [PDF]

Innate Immunity, 2013
ICAM-1 can be induced by inflammatory cytokines such as IFN-γ and TNF-α. This study investigated whether autophagy regulates ICAM-1 given that autophagy facilitates signaling of these two cytokines. Exogenous IFN-γ induced ICAM-1 in human lung epithelial A549 cells carrying wild type p53, a transcription factor reported for ICAM-1, but not in PC14PE6 ...
Chi-Yun, Wang, Tzu-Hui, Chiang, Chia-Ling, Chen, Po-Chun, Tseng, Shun-Yi, Chien, Yi-Jui, Chuang, Tsan-Tzu, Yang, Chia-Yuan, Hsieh, Pui-Ching, Choi, Chiou-Feng, Lin   +9 more
openaire   +2 more sources