The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway [PDF]
, 2018 Elevated body iron stores are associated with hypertension progression, while hypertension is associated with elevated plasma catecholamine levels in patients. However, there is a gap in our understanding of the connection between catecholamines and iron
Bao, Yongping +9 more
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Emerging roles of ATF2 and the dynamic AP1 network in cancer [PDF]
, 2010 Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course ...
A Behrens +228 more
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Development and validation of UPLC-MS/MS method for icariin and its metabolites in mouse urine
Frontiers in PharmacologyAn ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was utilized to develop a technique for the simultaneous quantification of icariin and its primary metabolites in mouse urine.
Na Li, Mei Yuan, Jinjing Che
doaj +1 more source
Electro-acupuncture promotes the proliferation of neural stem cells and the survival of neurons by downregulating miR-449a in rat with spinal cord injury [PDF]
, 2017 The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model ...
Wu, Yaochi, Zhang, Rong, Zhu, Yi
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Effect of troxerutin on serum glucose level and lactate dehydrogenase activity after exhaustive swimming in male rats [PDF]
, 2016 زمینه و هدف: ورزش وامانده ساز منجر به آسیب عضلانی و کاهش منابع انرژی نظیر گلوکز میشود. هدف مطالعه حاضر بررسی اثر مکمل تروگزروتین بر سطح سرمی گلوکز و فعالیت لاکتات دهیدروژناز متعاقب شنا وامانده ساز در موشهای صحرایی نر بود.
Hajizadeh, Mohammad Reza. +4 more
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Changes in apoptotic factors in hypothalamus and hippocampus after acute and subchronic stress induction during conditioned place preference paradigm [PDF]
, 2013 The hypothalamus (HYP) and hippocampus (HIP) are important regions involved in stress responses. These areas are also associated with reward processing.
Fatahi, Zahra +3 more
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Icariin ameliorates osteoporosis by activating autophagy in ovariectomized rats
Advances in Clinical and Experimental MedicineOsteoporosis (OP) is a major problem that increases the mortality and disability rate worldwide. With an increase in the aging population, OP has become a major public threat to human health. Searching for effective and suitable targets for drug treatment in OP has become an urgent need.Osteoporosis is a metabolic bone disease characterized by reduced ...
Jiaying, Zou +5 more
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Molecular mechanisms of endocrine disruptors: Interference with the endocrine system activity [PDF]
, 2018 Endocrine disrupting chemicals (EDCs) are an heterogeneous group of compounds able to interfere with hormonal functions by mimicking the endogenous hormones.
Falco, De, Laforgia, Vincenza
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Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms
Journal of Biological EngineeringAbstractThere is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of bone regeneration involves the transformation of mesenchymal stromal cells into osteoblasts and the subsequent mineralization of the extracellular matrix, making up the complex mechanism of ...
Mahsa Mohammadzadeh +4 more
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Effects and mechanisms of icariin on atherosclerosis.
International journal of clinical and experimental medicine, 2015 Icariin, a flavonoid isolated from the traditional Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to process anti-inflammatory, antioxidative actions and anti-atherosclerosis activity in vivo and in vitro. The purpose of this study was to investigate the effects and mechanisms of icariin on atherosclerosis by human umbilical vein ...
Yanwu, Hu +5 more
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