Results 41 to 50 of about 7,149 (225)

Protection of Icariin Against Hydrogen Peroxide‐Induced MC3T3‐E1 Cell Oxidative Damage

Orthopaedic Surgery, 2021
Objective The aim of the present study was to evaluate the potential protective mechanism of icariin against oxidative damage caused by hydrogen peroxide in MC3T3‐E1 cells.
Jian‐bin Sun, Zheng Wang, Wei‐jun An
doaj   +1 more source

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis [PDF]

Journal of Orthopaedic Surgery and Research, 2019
Abstract Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from Epimedium, has been preliminarily proven to show anti-osteoporotic and anti-inflammatory effects in OA. However,
Yan Zu, Yue Mu, Qiang Li, Shu-Ting Zhang, Hong-Juan Yan   +4 more
openaire   +3 more sources

Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering

Frontiers in Pharmacology, 2019
Icariin, a typical flavonol glycoside, is the main active component of Herba Epimedii, which was used to cure bone-related diseases in China for centuries.
Xin Zhang, Xin Zhang, Xingnan Lin, Tie Liu, Tie Liu, Liquan Deng, Yuanliang Huang, Yuelian Liu   +7 more
doaj   +1 more source

Icariin-Curcumol promotes docetaxel sensitivity in prostate cancer through modulation of the PI3K-Akt signaling pathway and the Warburg effect

Cancer Cell International, 2023
Background Docetaxel (DTX) resistance reduces therapeutic efficacy in prostate cancer (PCa). Accumulating reports support the role of phytochemicals in the reversal of DTX resistance. This study aimed to determine whether Epimedium brevicornu and Curcuma
Wenjing Xu, Jin Ding, Shida Kuang, Bonan Li, Tiansong Sun, Congxu Zhu, Juan Liu, Lemei Zhu, Yingqiu Li, Wen Sheng   +9 more
doaj   +1 more source

Improvement of solubility and pharmacokinetic profile of hepatoprotector icariin through complexation with HP-γ-cyclodextrin

Frontiers in Pharmacology, 2023
Icariin as a hepatoprotector from Herba epimedii can expand the cardiovascular and cerebral blood vessels, promote hematopoietic functions, enhance the immune system and show anti-liver tumor activities.
Yili Ding, Bo Yu, Shuzhen Zhou, Charles Ding, Zhiyuan Zhang, Shufeng Xu, Zhe Xu   +6 more
doaj   +1 more source

Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity [PDF]

, 2019
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid,
Altieri, Fabio, Cairone, Francesco, Carradori, Simone, Cesa, Stefania, Chichiarelli, Silvia, Giamogante, Flavia, Locatelli, Marcello   +6 more
core   +1 more source

Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice

Molecules, 2014
Icariin is effective in the treatment of hyperlipidemia. To understand the effect of icariin on lipid metabolism, effects of icariin on PPARα and its target genes were investigated.
Yuan-Fu Lu, Yun-Yan Xu, Feng Jin, Qin Wu, Jing-Shan Shi, Jie Liu   +5 more
doaj   +1 more source

Icariin Enhances Bone Repair in Rabbits with Bone Infection during Post-infection Treatment and Prevents Inhibition of Osteoblasts by Vancomycin

Frontiers in Pharmacology, 2017
Vancomycin is an effective antibiotic for treatment of bone infection caused by Staphylococcus aureus, however, a high local concentration of vancomycin might induce a delay in bone union.
Yang Zhang, Lifeng Shen, Zhujun Mao, Nani Wang, Xuping Wang, Xiaowen Huang, Ying Hu, Dan Shou, Chengping Wen   +8 more
doaj   +1 more source

Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms [PDF]

, 2015
published_or_final_versio
Lam, JKW, Lao, L, Ng, TB, Sze, CWS, Tong, Y, Wang, S, Zhang, Y, Zhang, Z   +7 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source