Results 61 to 70 of about 7,242 (224)

Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover

Molecules, 2019
Diabetic Osteoporosis (DOP) is a common metabolic bone disease, characterized by decreased bone mineral density (BMD) and destruction of bone microstructure.
Shanshan Qi, Jia He, Hongxing Zheng, Chen Chen, Shiqiang Lan   +4 more
doaj   +1 more source

Icariin negatively regulated lipopolysaccharide-induced inflammation and ameliorated the odontogenic activity of human dental pulp cells in vitro

Heliyon, 2023
Alleviating inflammation and promoting dentine regeneration is critical for the healing of pulpitis. In this study, we investigated the anti-inflammatory, angiogenesis and odontogenesis function of icariin on Human dental pulp cells (HDPCs) under ...
Guo Liu, Kkot-Byeol Bae, Ying Yang, Bin-Na Lee, Yun-Chan Hwang   +4 more
doaj   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Evaluation of Osteogenesis and Angiogenesis of Icariin in Local Controlled Release and Systemic Delivery for Calvarial Defect in Ovariectomized Rats

Scientific Reports, 2017
Typically, bone regenerative medicine is applied to repair bone defects in patients with osteoporosis. Meanwhile, there is an urgent need to develop safe and cheap drugs that induce bone formation.
Yuqiong Wu, LingYan Cao, Lunguo Xia, Qianju Wu, Jie Wang, Xiao Wang, Lianyi Xu, Yuning Zhou, Yuanjin Xu, Xinquan Jiang   +9 more
doaj   +1 more source

Enhancement of Epimedium Fried with Suet Oil Based on in Vivo Formation of Self-Assembled Flavonoid Compound Nanomicelles

Molecules, 2012
The purpose of this work was to research the enhancement of Epimedium fried with suet oil based on the in vivo formation self-assembled flavonoid nanomicelles.
Xiao-Bin Jia, Xin Jin, Ying-Jie Wei, Xiao-Bin Tan, Zhen-Hai Zhang, Li Cui, E Sun   +6 more
doaj   +1 more source

Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs

Molecular Therapy: Nucleic Acids, 2021
Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, the underlying mechanism remains unclear. In
Shan Liu, Dong-sheng Xu, Min Li, Yang Zhang, Qi Li, Teng-teng Li, Li-qun Ren   +6 more
doaj   +1 more source

Emerging Treatments for Erectile Dysfunction

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent condition that can significantly affect men's sexual health and quality of life, and for which there are many well‐studied effective treatments. In spite of this, many individuals still seek out alternative therapies.
Resa Magill, Jeff Morrison, Juan Andino, Jasper Bash   +3 more
wiley   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Anti-inflammatory and immunoregulatory effects of icariin and icaritin

Biomedicine & Pharmacotherapy, 2022
Inflammation and immunity dysregulation have received widespread attention in recent years due to their occurrence in the pathophysiology of many conditions. In this regard, several pharmacological studies have been conducted aiming to evaluate the potential anti-inflammatory and immunomodulatory effects of phytochemicals.
Zhangyang, Bi, Wei, Zhang, Xiaoyan, Yan
openaire   +2 more sources

Comprehensive study for investigating the mechanisms by which dietary icariin prevents ferroptosis in aged-related osteoporosis

Food Science and Human Wellness
Icariin is a natural product that possesses numerous pharmaceutical properties. Thus, this study aimed to investigate the molecular mechanism by which icariin prevents ferroptosis in aged-related osteoporosis.
Maopeng Wang, Yuanlin Wang, Yong Zeng, Zhipeng Tian, Liuhai Xu, Xinzhi Li, Lei Wang, Bing Li, You Zhou, Jun Liu   +9 more
doaj   +1 more source