Results 71 to 80 of about 7,242 (224)

New pathway of icariin-induced MSC osteogenesis: transcriptional activation of TAZ/Runx2 by PI3K/Akt

Open Life Sciences, 2017
Icariin has been demonstrated to stimulate mesenchymal stem cell (MSC) osteogensis and activate several signals, such as PI3K/Akt, but how the osteogenesis was sequentially mediated is unclear.
Zhang Guoying, Cheng Xiaofei, Zhou Gongshe, Xue Huimin, Shao Shan, Wang Zheng   +5 more
doaj   +1 more source

HIF-1 signalling pathway was identified as a potential new pathway for Icariin’s treatment against Alzheimer’s disease based on preclinical evidence and bioinformatics

Frontiers in Pharmacology, 2022
Aim: Alzheimer’s disease (AD) is a neurodegenerative condition that is characterized by the gradual loss of memory and cognitive function. Icariin, which is a natural chemical isolated from Epimedii herba, has been shown to protect against AD.
Mingyao You, Ping Yuan, Liangqian Li, Hongbei Xu   +3 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A novel icariin type flavonoid from Epimedium pseudowushanense

Natural Product Research, 2018
A novel icariin type flavonoid glycoside with a malonaldehydic acid intramolecular ester and two known flavonoid glycosides were isolated from Epimedium pseudowushanense. Their structures were elucidated on the basis of spectroscopic analysis and comparison of their data to the values reported in the literatures.
Huihui Ti, Ping Wu, Liangxiong Xu, Xiaoyi Wei   +3 more
openaire   +2 more sources

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases [PDF]

, 2015
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society.
A Gutierrez-Zepeda, A Hornsten, A Lublin, A Murakami, A Tauffenberger, A Teixeira-Castro, A Teixeira-Castro, A Vaccaro, Alan Morgan, AR Burns, AV McCormick, B Lakowski, B Wolozin, BA Benitez, BB Kautu, BC Kraemer, BH Shin, BP Hubbard, C Fatouros, C Frokjaer-Jensen, C Soto, C Voisine, C Yao, CD Link, CD Link, CD Link, CD Link, CI Nussbaum-Krammer, CJ Locke, CY Ewald, D Levitan, DC Swinney, DC Swinney, DE Ehrnhoefer, DF Silva, DF Tardiff, DP Karpinar, DS Fay, E Braungart, EM Mandelkow, F Aparecida Paiva, F Cabreiro, F-X Lejeune, G McColl, G Pani, H Varma, H Wang, H Witan, HR Brignull, HV McCue, J Drake, J Li, J Liu, J Parker, J Parker, J Sämann, J Wang, JA Baur, JA Hardaway, Jeff W. Barclay, JF Morley, JN Sleigh, JP Taylor, JS Sangha, JV Smith, JW Barclay, K Evason, K Yamanaka, K-W Park, KA Caldwell, KE Matlack, L Diomede, L Diomede, L Noskova, L Xiao, LE Dosanjh, LS Schneider, M Briese, M Cadieux-Dion, M Haltia, M Haltia, M Lakso, M Marvanova, M Velinov, ML Florez-McClure, N Bizat, N Bizat, N Wittenburg, NF Liachko, NF Liachko, NT Christie, P Haldimann, PE Ash, PJ Muchowski, PW Faber, Q Ruan, R Brandt, R Keowkase, R Nass, R Nass, R Ved, R-H Fu, R-H Fu, RA Weiss, RD Burgoyne, Robert D. Burgoyne, S Abbas, S Abbas, S Alavez, S Amor, S Ayyadevara, S Buttner, S Cao, S Hamamichi, S Jagota, S Saha, S Treusch, SH Satyal, SJ Park, SM Yatin, SS Karuppagounder, SS Kashyap, T Gidalevitz, T Ham van, T Kuwahara, T Kuwahara, T Kuwahara, T Miyasaka, T Oeda, T Zhang, TJ Ham van, TT Ching, U Arya, V Crunelli, V Dostal, W Springer, X Chen, X Chen, X Yang, Xi Chen, Y Wu, Z Liu   +141 more
core   +1 more source

A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

Mediators of Inflammation, 2014
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that causes deformity of the joints and physical disability. Icariin, a natural flavonoid glucoside isolated from plants in the Epimedium family, has been proven to have various ...
Liqun Chi, Wenyuan Gao, Xiangrong Shu, Xin Lu   +3 more
doaj   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

The Herbal Pair Daphniphyllum calycinum–Polygonum hydropiper Alleviates Gastric Mucosal Injury via Regulating Autophagy and Targeting the TLR4/NF‐κB/NLRP3 Pathway

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The schematic diagram illustrated the proposed mechanism of DCPH in mouse macrophages. DCPH promotes autophagy to suppress the TLR4/NF‐κB/NLRP3 pathway and M1 polarization, thereby attenuating cellular oxidative stress and inflammation. ABSTRACT Gastric mucosal injury refers to the pathological changes characterized by congestion, edema, bleeding and ...
Yunyun Zhi, Keli Zhou, Xueqing Huang, Yonghui Li, Ye Zhu, Yiqiang Xie, Shouzhong Ren   +6 more
wiley   +1 more source

Icariside II Preparation from Icariin Separated from Epimedium Herbal Extract Powder by a Special Icariin Glycosidase

Journal of Microbiology and Biotechnology
In this study, icariside II was prepared from icariin by a special enzyme. The yield of the substrate icariin from a powdered extract of the popular herb Epimedium was 16.9%. The enzyme, which was produced from Aspergillus sp.y48 fermentation, hydrolyzes icariin to icariside II and was characterized.
Liu, Xinyu, Xu, Siyu, Liu, Chunying, Wang, Zhenghao, Wu, Bo, Guo, Meijuan, Sun, Changkai, Yu, Hongshan   +7 more
openaire   +2 more sources

Macrophage inhibits the osteogenesis of fibroblasts in ultrahigh molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis [PDF]

, 2019
Background In the ultrahigh molecular weight polyethylene (UHMWPE) prosthetic environment, fibroblasts affected by wear particles have the capacity of osteogenesis to reduce osteolysis.
Dai, Zixun, Hu, Yihe, Lei, Pengfei, Li, Kun, Liu, Huan, Niu, Wanting, Wang, Long, Xie, Jie, Zhang, Yu S, Zhang, Yu Shrike   +9 more
core   +1 more source