Results 81 to 90 of about 7,242 (224)

The Protective Effects of Icariin against the Homocysteine-Induced Neurotoxicity in the Primary Embryonic Cultures of Rat Cortical Neurons

Molecules, 2016
Icariin, an ingredient in the medicinal herb Epimedium brevicornum Maxim (EbM), has been considered as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer’s disease (AD).
Xiao-Ang Li, Yuen-Shan HO, Lei Chen, W.L. Wendy Hsiao   +3 more
doaj   +1 more source

Chemical markers for the quality control of herbal medicines: an overview [PDF]

, 2008
Selection of chemical markers is crucial for the quality control of herbal medicines, including authentication of genuine species, harvesting the best quality raw materials, evaluation of post-harvesting handling, assessment of intermediates and finished
Songlin Li, Quanbin Han, Chunfeng Qiao, Jingzheng Song, Chuen Lung Cheng, Hongxi Xu   +5 more
core   +2 more sources

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Human Safety and Pharmacokinetics Study of Orally Administered Icariin: Randomized, Double-Blind, Placebo-Controlled Trial

Natural Product Communications, 2019
Preclinical literature suggests that icariin, a flavonoid found in Epimedium , may have potential for medical and psychiatric conditions. The objective of this study was to examine the safety, tolerability, and pharmacokinetics of orally administered ...
E. Sherwood Brown, Collette Bice, William C. Putnam, Richard Leff, Alexandra Kulikova, Alyson Nakamura, Elena I. Ivleva, Erin Van Enkevort, Traci Holmes, Nyokabi Miingi   +9 more
doaj   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Icariin reduces cadmium-induced renal injury in rats

Food and Chemical Toxicology
Icariin (ICA), an active ingredient found in Epimedium, possesses antioxidant and anti-inflammatory properties and has garnered widespread attention in recent years. This study investigated the protective effects of ICA against cadmium (Cd)-induced kidney injury in rats. Healthy male specific pathogen-free Sprague-Dawley rats were randomly divided into
Jiewei, Zheng, Xin, Yang, Cong, Zhang, Weipeng, Zhang, Yue, Hu, Lihai, Zeng, Lili, Liu, Guoliang, Li   +7 more
openaire   +2 more sources

Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Frontiers in Pharmacology, 2018
Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic ...
Mingxin Li, Yemin Zhang, Yingkang Cao, Deling Zhang, Le Liu, Yanghongyun Guo, Changhua Wang   +6 more
doaj   +1 more source

Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Frontiers in Pharmacology, 2020
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting.
Haixia Zhao, Haixia Zhao, Xu You, Qian Chen, Qian Chen, Siqi Yang, Qiongyan Ma, Yumin He, Yumin He, Chaoqi Liu, Yaoyan Dun, Jie Wu, Changcheng Zhang, Changcheng Zhang, Ding Yuan   +14 more
doaj   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Physically crosslinked poly(vinyl alcohol)-based hydrogels for cartilage tissue engineering

Materials & Design
Due to the limited self-healing ability of cartilage, cartilage defect repair remains a challenge in clinical treatment. Therefore, there is a need to provide patients with a promising cartilage defect repair strategy.
Changxin Xiang, Zijian Guo, Qing Zhang, Zehua Wang, Xiaona Li, Weiyi Chen, Xiaochun Wei, Pengcui Li, Chuan Xiang   +8 more
doaj   +1 more source