Results 111 to 120 of about 271,547 (325)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang   +13 more
wiley   +1 more source

DSM-5 and ICD-11 as competing models of PTSD in preadolescent children exposed to a natural disaster: assessing validity and co-occurring symptomatology

open access: yesEuropean Journal of Psychotraumatology, 2017
Background: Major revisions have been made to the DSM and ICD models of post-traumatic stress disorder (PTSD). However, it is not known whether these models fit children’s post-trauma responses, even though children are a vulnerable population following ...
Annette M. La Greca   +2 more
doaj   +1 more source

The modern concept of schizoaffective disorder: a narrative review [PDF]

open access: yesConsortium Psychiatricum
BACKGROUND: Schizoaffective disorder (SAD) is one of the most complex and controversial diagnoses in clinical psychiatry. Despite the significant changes that have occurred in the conceptualization of SAD in modern classifications and the publications of
Aleksey V. Pavlichenko   +2 more
doaj   +1 more source

Persistence and Psychological Predictors of ICD-11 Complex PTSD: A Six-Month Longitudinal Study in Hong Kong [PDF]

open access: hybrid, 2023
Stanley Kam Ki Lam   +4 more
openalex   +1 more source

ICD-11: WHO eröffnet Kommentierungsphase

open access: yesGMS Mitteilungen aus der AWMF, 2016
Die WHO hat jüngst bei ihrer Revision Conference in Tokio die revidierte Internationale Klassifikation der Krankheiten (ICD-11) vorgestellt. Sie soll 2018 fertiggestellt und verabschiedet werden. WHO-Generaldirektorin Margaret Chan hat daher die Mitgliedsländer eingeladen, die neue Version zu testen und zu kommentieren.
openaire   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

open access: yesAdvanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha   +7 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

The classification of feeding and eating disorders in the ICD-11: results of a field study comparing proposed ICD-11 guidelines with existing ICD-10 guidelines

open access: yesBMC Medicine, 2019
Background The World Health Organization (WHO) International Classification of Diseases and Related Health Problems (ICD) is used globally by 194 WHO member nations.
Angélica M. Claudino   +20 more
doaj   +1 more source

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