Results 181 to 190 of about 306,492 (342)
Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs
Advanced Science, EarlyView.This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi +31 morewiley +1 more sourceTop‐Down Fabricated Wood‐Derived Pressure and Strain Sensors: A Review
Advanced Science, EarlyView.This review focuses on wood‐derived pressure/strain sensors fabricated via top‐down strategies. It analyzes wood's structural composition, examines processing techniques, discusses sensor types and sensing mechanisms, and reviews existing research. The article concludes with future directions for enhancing performance and scalability.Yi Ren, Fuyao Liu, Yanan Zhong, Shengbo Ge, Zhipeng Shi, Siling Lin, Hongli Song, Yingying Zhang, Wei Fan +8 morewiley +1 more sourceHPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4
Advanced Science, EarlyView.This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan +17 morewiley +1 more sourceResults of ISMIP6 CMIP6 forced simulations: a multi-model ensemble of the Greenland and Antarctic ice sheet evolution over the 21st century
, 2021 A. J. Payne, Sophie Nowicki, Ayako Abe‐Ouchi, Cécile Agosta, Patrick Alexander, Torsten Albrecht, Xylar Asay‐Davis, Andy Aschwanden, Alice Barthel, Thomas J. Bracegirdle, Reinhard Calov, Christopher Chambers, Youngmin Choi, Richard Cullather, Joshua Cuzzone, Christophe Dumas, Tamsin Edwards, F. Denis, Xavier Fettweis, Benjamin K. Galton‐Fenzi, Heiko Goelzer, Rupert Gladstone, Nicholas R. Golledge, Jonathan M. Gregory, Ralf Greve, Tore Hattermann, Matthew J. Hoffman, Angelika Humbert, Philippe Huybrechts, Nicolas C. Jourdain, Thomas Kleiner, Peter Kuipers Munneke, Eric Larour, Sébastien Le clec’h, Victoria Lee, Gunter Leguy, William H. Lipscomb, Christopher M. Little, Daniel P. Lowry, Mathieu Morlighem, Isabel Nias, Frank Pattyn, Tyler Pelle, Stephen Price, Aurélien Quiquet, Ronja Reese, Martin Rückamp, Nicole‐Jeanne Schlegel, Hélène Seroussi, Andrew Shepherd, Erika Simon, Donald Slater, Robin S. Smith, Fiammetta Straneo, Sainan Sun, Lev Tarasov, Luke D. Trusel, Jonas Van Breedam, Roderik S. W. van de Wal, M. R. van den Broeke, Ricarda Winkelmann, Chen Zhao, Tong Zhang, Thomas Zwinger +63 moreopenalex +2 more sourcesDe Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems
Advanced Science, EarlyView.EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita +18 morewiley +1 more sourceA Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer
Advanced Science, EarlyView.Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari +11 morewiley +1 more sourceNurr1 Orchestrates Claustrum Development and Functionality
Advanced Science, EarlyView.Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin +12 morewiley +1 more source
