Results 51 to 60 of about 122,661 (305)

The Glimmer community ice sheet model [PDF]

Journal of Geophysical Research: Earth Surface, 2009
We present a detailed description of the Glimmer ice sheet model, comprising the physics represented in the model and the numerical techniques used. Established methods are combined with good software design to yield an adaptable and widely applicable model. A flexible framework for coupling Glimmer to global climate forcing is also described.
Rutt, IC, M., Hagdorn, N.R.J., Hulton, Payne, AJ   +3 more
openaire   +4 more sources

The shallow shelf approximation as a "sliding law" in a thermomechanically coupled ice sheet model

, 2008
The shallow shelf approximation is a better ``sliding law'' for ice sheet modeling than those sliding laws in which basal velocity is a function of driving stress.
Aschwanden, Balay, Blatter, Bueler, Bueler, Clarke, Ed Bueler, Fowler, Fowler, Greve, Greve, Greve, Greve, Hindmarsh, Hindmarsh, Howat, Hulbe, Hutter, Huybrechts, Huybrechts, Jed Brown, Jenssen, Johnson, Joughin, Joughin, Joughin, Joughin, MacAyeal, MacAyeal, Mahaffy, Marshall, Marshall, Marshall, Morland, Morland, Morton, Paterson, Paterson, Pattyn, Pattyn, Payne, Pollard, Raymond, Ritz, Ritz, Saad, Saito, Saito, Saito, Schoof, Schoof, Schoof, Schoof, Shepherd, Tarasov, Truffer, Truffer, Tulaczyk, Tulaczyk, Vaughan, Weis, Wesseling, Zwally, Zwinger   +63 more
core   +1 more source

Controls on interior West Antarctic Ice Sheet Elevations: inferences from geologic constraints and ice sheet modeling [PDF]

, 2013
Knowledge of the West Antarctic Ice Sheet (WAIS) response to past sea level and climate forcing is necessary to predict its response to warmer temperatures in the future.
Ackert Jr., Robert P., Borns Jr., Harold W., DeConto, Robert M., Kurz, Mark D., Mukhopadhyay, Sujoy, Pollard, David, Putnam, Aaron Ervin   +6 more
core   +2 more sources

Coupled Climate‐Ice‐Sheet Simulations Reveal Novel Teleconnection Between Northern Hemisphere Ice Sheets and the Antarctic Ice Sheet

Geophysical Research Letters
Coupled climate‐ice‐sheet modeling is still in its developing stage, and feedback processes between ice sheets and climate are still not yet fully understood.
Pierre Testorf, Clemens Schannwell, Marie‐Luise Kapsch, Uwe Mikolajewicz   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Modeling Antarctic ice sheet loss [PDF]

Science, 2019
Cryosphere Knowledge of the speed and scale of ice-shelf melting in Antarctica is crucial for estimates of ice sheet loss. How accurate do models need to be to capture these processes and yield useful projections of future ice sheet loss and the resulting sea level rise? To address this question, Goldberg et al.
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A stochastic parameterization of ice sheet surface mass balance for the Stochastic Ice-Sheet and Sea-Level System Model (StISSM v1.0) [PDF]

Geoscientific Model Development
Many scientific and societal questions that draw on ice sheet modeling necessitate sampling a wide range of potential climatic changes and realizations of internal climate variability.
L. Ultee, L. Ultee, A. A. Robel, S. Castruccio   +3 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Engineered Mycelial Scaffolds With Tunable Ultraviolet Protection, Wettability, Thermal Stability, and Spatial Mechanics

Advanced Engineering Materials, EarlyView.
Fungal mycelia grown into biodegradable scaffolds and infused with titania nanoparticles show enhanced ultraviolet shielding, thermal protection, and surface nonwettability. Properties were tuned by drying methods, revealing structure–function relationships.
Juwon S. Afolayan, Xin Zhang, Carole C. Perry   +2 more
wiley   +1 more source