Results 101 to 110 of about 1,452,016 (315)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The effect of ice rubble on ice-ice sliding [PDF]

, 2015
Ice deformation processes in the Arctic can generate ice rubble. Many situations arise where ice fragments of varying size separate sea ice floes. While the shear forces between sea ice floes in direct contact with each other are controlled by ice-ice friction, what is not known is how the slip of the floes is affected by the presence of rubble between
Scourfield, Sally, Sammonds, Peter, Lishman, Ben, Marchenko, Aleksey   +3 more
openaire  

Inquiry into 'ice' use in the Northern Territory

, 2015
Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Committee members -- Committee Secretariat -- Acknowledgments -- Acronyms and abbreviations -- Terms of reference -- Executive summary -- Recommendations -
Northern Territory Legislative Assembly. 'Ice" Select Committee
core  

The Aerodynamic Effects of Runback Ice [PDF]

, 2013
The objectives of this PhD were to investigate the aerodynamic performance effects due to runback ice accretion with particular interest on the EASA 45 minute hold case in icing conditions. The sponsors, Airbus and Cranfield University collaboratively
Parmar, Krishan
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Novel Multidimensional Statistics Denoising Algorithm Based on Gaussian Mixture Model for Photon-Counting LiDAR Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The micropulse multibeam photon-counting laser altimeter significantly improves the sampling density along the orbit while introducing abundant noise.
Sitong Chen, Sheng Nie, Xiaohuan Xi, Shaobo Xia, Feng Zhu, Cheng Wang, Xiaoxiao Zhu   +6 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Peridynamic Simulation of the Penetration of an Ice Sheet by a Vertically Ascending Cylinder

Journal of Marine Science and Engineering
The vertical ice breaking of marine structures in ice-covered areas involves the deformation and failure of an ice sheet. Different from the existing conventional scenarios where the ice sheet is used as a transportation and support medium, the damage to
Bin Jia, Qing Wang, Lei Ju, Chenjun Hu, Rongsheng Zhao, Duanfeng Han, Fuzhen Pang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A New Guitar Teaching Philosophy A New Guitar Teaching Philosophy

Acta Universitaria, 2012
In this present work it is given an opinion for a new approach to guitar teaching philosophy in a sufficiently sophisticated way, which surpasses up to now all known looks. With a goal to shed light on this important topic, this work will introduce a new
Ice B. Risteski
doaj