Results 81 to 90 of about 1,713,620 (300)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Peridynamic Simulation of the Penetration of an Ice Sheet by a Vertically Ascending Cylinder

Journal of Marine Science and Engineering
The vertical ice breaking of marine structures in ice-covered areas involves the deformation and failure of an ice sheet. Different from the existing conventional scenarios where the ice sheet is used as a transportation and support medium, the damage to
Bin Jia, Qing Wang, Lei Ju, Chenjun Hu, Rongsheng Zhao, Duanfeng Han, Fuzhen Pang   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

A physically-based formulation for texture evolution during dynamic recrystallization. A case study of ice

Comptes Rendus. Mécanique
Dynamic recrystallization can have a strong impact on texture development during the deformation of polycrystalline materials at high temperatures, particularly for materials with strong viscoplastic anisotropy such as ice.
Chauve, Thomas, Montagnat, Maurine, Dansereau, Véronique, Saramito, Pierre, Fourteau, Kévin, Tommasi, Andréa   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Hydrometeorological hazards on radiation contaminated territories of the East Ural region of Russia

Наука. Инновации. Технологии, 2022
In work possibility of influence of the dangerous hydrometeorological phenomena on character and scales of distribution of radioactive pollution of environment within radiation polluted areas is shown.
Victor Vladimirovich Razumov, Natalia Victorovna Razumova   +1 more
doaj  

The anomalous pressure drop behaviour of ice slurries flowing through constrictions [PDF]

, 2008
The effective ‘viscosity’ for ice slurry containing more than say 30 to 40% ice fraction is many orders of magnitude higher than that for water. However, this work suggests that such slurries, when flowing through constrictions, can incur lower pressure ...
Rhys, T. D. L., Evans, T. S., Quarini, Giuseppe Leonardo, Shire, G. S. F.   +3 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

FACTORS AFFECTING THE CONDITIONS OF SULFATE REDUCTION AND MERCURY METHYLATION IN THE RIVER AMUR ICE

Лëд и снег, 2018
Results of the layer-by-layer studies of distribution of organic matter (OM) and mercury in ice cores sampled from the Amur River near the Khabarovsk city: its mainstream and the Pemzenskaya and Amurskaya branches, are presented.
L. M. Kondratyeva, D. V. Andreeva, E. M. Golubeva   +2 more
doaj   +1 more source