Results 81 to 90 of about 1,621,280 (286)

The effect of ice rubble on ice-ice sliding [PDF]

, 2015
Ice deformation processes in the Arctic can generate ice rubble. Many situations arise where ice fragments of varying size separate sea ice floes. While the shear forces between sea ice floes in direct contact with each other are controlled by ice-ice friction, what is not known is how the slip of the floes is affected by the presence of rubble between
Scourfield, Sally, Sammonds, Peter, Lishman, Ben, Marchenko, Aleksey   +3 more
openaire  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A New Guitar Teaching Philosophy A New Guitar Teaching Philosophy

Acta Universitaria, 2012
In this present work it is given an opinion for a new approach to guitar teaching philosophy in a sufficiently sophisticated way, which surpasses up to now all known looks. With a goal to shed light on this important topic, this work will introduce a new
Ice B. Risteski
doaj  

A Novel Multidimensional Statistics Denoising Algorithm Based on Gaussian Mixture Model for Photon-Counting LiDAR Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The micropulse multibeam photon-counting laser altimeter significantly improves the sampling density along the orbit while introducing abundant noise.
Sitong Chen, Sheng Nie, Xiaohuan Xi, Shaobo Xia, Feng Zhu, Cheng Wang, Xiaoxiao Zhu   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Peridynamic Simulation of the Penetration of an Ice Sheet by a Vertically Ascending Cylinder

Journal of Marine Science and Engineering
The vertical ice breaking of marine structures in ice-covered areas involves the deformation and failure of an ice sheet. Different from the existing conventional scenarios where the ice sheet is used as a transportation and support medium, the damage to
Bin Jia, Qing Wang, Lei Ju, Chenjun Hu, Rongsheng Zhao, Duanfeng Han, Fuzhen Pang   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sea and Freshwater Ice Concentration from VIIRS on Suomi NPP and the Future JPSS Satellites

Remote Sensing, 2016
Information on ice is important for shipping, weather forecasting, and climate monitoring. Historically, ice cover has been detected and ice concentration has been measured using relatively low-resolution space-based passive microwave data.
Yinghui Liu, Jeffrey Key, Robert Mahoney
doaj   +1 more source