Results 61 to 70 of about 1,124,625 (265)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Comparative Study of Measurement Methods for Investigation of Electrical Discharges in Nanofunctionalized Transformer Oils

IEEE Access
The development of nanofunctionalized transformer oils has sparked growing interest in understanding their electrical discharge behavior. This review presents a comprehensive analysis of diagnostic methods used to investigate partial discharges and ...
Kristian Glajc, Michal Rajnak, Juraj Kurimsky   +2 more
doaj   +1 more source

ICE VII, THE DENSEST FORM OF ICE

Proceedings of the National Academy of Sciences, 1964
In the pressure range 0-25 kilobars there occur 7 different crystalline modifications of ice,(1) whereas from 25 kbar up to the highest pressure so far tried, 200 kbar, only a single form occurs:(2) ice VII, of density about 1.7 gm cm^-3. Ice VII thus seems in some sense to be an "ultimate" crystalline form of ice, and its structure is therefore of ...
B, Kamb, B L, Davis
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Object-Background Blending Augmentation Method for Object Detection Systems

IEEE Access
Reliable object detection in aerial imagery is critical for applications such as drone surveillance, disaster monitoring, and infrastructure protection.
Ladislav Hric, Jan Bacik, Daniela Perdukova   +2 more
doaj   +1 more source

Hydrometeorological hazards on radiation contaminated territories of the East Ural region of Russia

Наука. Инновации. Технологии, 2022
In work possibility of influence of the dangerous hydrometeorological phenomena on character and scales of distribution of radioactive pollution of environment within radiation polluted areas is shown.
Victor Vladimirovich Razumov, Natalia Victorovna Razumova   +1 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A New Guitar Teaching Philosophy A New Guitar Teaching Philosophy

Acta Universitaria, 2012
In this present work it is given an opinion for a new approach to guitar teaching philosophy in a sufficiently sophisticated way, which surpasses up to now all known looks. With a goal to shed light on this important topic, this work will introduce a new
Ice B. Risteski
doaj  

The effect of ice rubble on ice-ice sliding [PDF]

, 2015
Ice deformation processes in the Arctic can generate ice rubble. Many situations arise where ice fragments of varying size separate sea ice floes. While the shear forces between sea ice floes in direct contact with each other are controlled by ice-ice friction, what is not known is how the slip of the floes is affected by the presence of rubble between
Scourfield, Sally, Sammonds, Peter, Lishman, Ben, Marchenko, Aleksey   +3 more
openaire