Results 51 to 60 of about 1,452,016 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Systematic Benchmark of Reinforcement Learning Formulations for Tendon-Driven Continuum Robot Control

open access: yesIEEE Access
Continuum robots are well suited to confined and contact-rich environments, but their control remains challenging because modeling fidelity, computational cost, and real-time feasibility are often in tension.
Darius Rusinak   +2 more
doaj   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

open access: yes, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J.   +17 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]

open access: yes, 2010
The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN   +1 more
core  

The anomalous pressure drop behaviour of ice slurries flowing through constrictions [PDF]

open access: yes, 2008
The effective ‘viscosity’ for ice slurry containing more than say 30 to 40% ice fraction is many orders of magnitude higher than that for water. However, this work suggests that such slurries, when flowing through constrictions, can incur lower pressure ...
Rhys, T. D. L.   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Matrix method for solving linear complex vector functional equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2002
We give a new matrix method for solving both homogeneous and nonhomogeneous linear complex vector functional equations with constant complex coefficients.
Ice B. Risteski
doaj   +1 more source

Combined mini-TPP based on gas piston installation and steam turbine

open access: yesИзвестия высших учебных заведений: Проблемы энергетики, 2017
The paper proposes a technological scheme of the combined mini-TPP on the basis of gas-piston installation and a steam turbine, which may be required as part of the local or distributed power systems.
P. A. Shchinnikov, N. V. Marasanov
doaj   +1 more source

A Novel Approach to Map the Intensity of Surface Melting on the Antarctica Ice Sheet Using SMAP L-Band Microwave Radiometry

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2022
The polar ice sheets have undergone unprecedented melt events in recent years, which have consequences for the ice sheet mass balance and stability, and global sea level.
Mohammad Mousavi   +3 more
doaj   +1 more source

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