Results 41 to 50 of about 1,124,625 (265)

A Deep Reinforcement Learning Framework for Centralized Dynamic Routing Optimization via Integrated Link Weight Prediction and Path Selection

IEEE Access
Traditional routing protocols such as OSPF rely on static metrics, failing to account for real-time link utilization. This static approach often directs traffic to congested bottlenecks while redundant paths remain idle, leading to increased latency ...
Erika A. Katonova, Juraj Jurcisin, Rastislav Petija, Eugen Slapak, Peter Fecilak   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Signal Prediction Using U-Net CNN: Beyond Traditional RNN Approaches

IEEE Access
This paper studies signal prediction in settings where the target signal is not a continuation of an observed history but must be inferred from other simultaneously measured signals.
Marek Ruzicka, Martin Muzelak, Juraj Gazda, Tomas Skovranek   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Stellar encounters in the solar neighbourhood and the special case of GJ 710

Astronomy & Astrophysics
Aims. We present a comprehensive characterisation of close stellar encounters in the solar vicinity, with a particular focus on placing the predicted fly-by of GJ 710 in context.
Fernandez-Puig Eloi, Morales Juan Carlos, Ribas Ignasi, Laguna-Miralles Júlia, Guijosa Pol   +4 more
doaj   +1 more source

Modeling ice block failure within drift ice and ice rubble

Physical Review E, 2022
A major challenge within material science is the proper modeling of force transmission through fragmenting materials under compression. A particularly demanding material is sea ice, which on small scales is an anisotropic material with quasibrittle characteristics under failure.
Polojärvi, Arttu, Wei, Mingdong, Åström, Jan, Prasanna, Malith   +4 more
openaire   +4 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

MASSIVE: A scalable framework for agent-based scheduling of micro-grids using market mechanisms

Energy Informatics
With the increasing share of distributed renewable energy sources the need arises to store excess energy and/or to shift demands to match the given supply. To coordinate multiple suppliers and demands in a local energy-system different control approaches
Jakob M. Fritz, Lea Riebesel, André Xhonneux, Dirk Müller   +3 more
doaj   +1 more source

Assessment of Runway Surface Conditions by British Pendulum Testing under the Global Reporting Format Winter Conditions

Applied Sciences, 2022
Poor braking performance on runways during winter is one of the most significant factors causing runway excursions. The International Civil Aviation Organization (ICAO) proposed a standardized method, named the Global Reporting Format (GRF), to establish
Jean-Denis Brassard, Audrey Beaulieu, Marc Mario Tremblay, Gelareh Momen   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source