Results 121 to 130 of about 3,621,494 (339)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Degeneracy and criticality from emergent frustration in artificial spin ice
, 2013 Although initially introduced to mimic the spin-ice pyrochlores, no artificial spin ice has yet exhibited the expected degenerate ice-phase with critical correlations similar to the celebrated Coulomb phase in the pyrochlore lattice.
Chern, Gia-Wei +2 more
core +1 more source
Magical spherical ice (ice balls, ice eggs)
Journal of Lake Sciences, 2022 Xie Fei +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Surface Expression of Ice Segregation: Needle Ice, Pebble Ice, Ice Flowers and Hair Ice
Journal of Geography and Earth Sciences, 2021 James R. Carter, Emeritus Professor
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
EnergiesIce accumulation on heating, ventilation, air conditioning, and refrigeration (HVACR) structures presents significant operational challenges. These challenges include reduced efficiency, increased energy consumption, and potential damage to equipment ...
Hongbin Sun, Praveen Cheekatamarla
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Dynamic Characteristic of System Thermal Conductivity during the Process of Water-ice Phase Change
Zhileng xuebao, 2018 The Hot Disk thermal constant analyzer based on transient plane source technology is used to study the variation in ice thermal conductivity during the formation and melting.
Sun Shicai +4 more
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